Nature Communications (Jul 2019)
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response
- Adebowale A. Adeyemo,
- Norann A. Zaghloul,
- Guanjie Chen,
- Ayo P. Doumatey,
- Carmen C. Leitch,
- Timothy L. Hostelley,
- Jessica E. Nesmith,
- Jie Zhou,
- Amy R. Bentley,
- Daniel Shriner,
- Olufemi Fasanmade,
- Godfrey Okafor,
- Benjamin Eghan,
- Kofi Agyenim-Boateng,
- Settara Chandrasekharappa,
- Jokotade Adeleye,
- William Balogun,
- Samuel Owusu,
- Albert Amoah,
- Joseph Acheampong,
- Thomas Johnson,
- Johnnie Oli,
- Clement Adebamowo,
- South Africa Zulu Type 2 Diabetes Case-Control Study,
- Francis Collins,
- Georgia Dunston,
- Charles N. Rotimi
Affiliations
- Adebowale A. Adeyemo
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Norann A. Zaghloul
- Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine
- Guanjie Chen
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Ayo P. Doumatey
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Carmen C. Leitch
- Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine
- Timothy L. Hostelley
- Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine
- Jessica E. Nesmith
- Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine
- Jie Zhou
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Amy R. Bentley
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Daniel Shriner
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Olufemi Fasanmade
- University of Lagos
- Godfrey Okafor
- University of Nigeria Teaching Hospital
- Benjamin Eghan
- University of Science and Technology
- Kofi Agyenim-Boateng
- University of Science and Technology
- Settara Chandrasekharappa
- National Human Genome Research Institute, National Institutes of Health
- Jokotade Adeleye
- College of Medicine, University of Ibadan
- William Balogun
- College of Medicine, University of Ibadan
- Samuel Owusu
- University of Ghana Medical School
- Albert Amoah
- University of Ghana Medical School
- Joseph Acheampong
- University of Science and Technology
- Thomas Johnson
- University of Lagos
- Johnnie Oli
- University of Nigeria Teaching Hospital
- Clement Adebamowo
- Department of Epidemiology and Public Health; Institute of Human Virology; Greenebaum Comprehensive Cancer Center, School of Medicine, University of Maryland
- South Africa Zulu Type 2 Diabetes Case-Control Study
- Oxford NIHR Biomedical Research Centre
- Francis Collins
- National Institutes of Health
- Georgia Dunston
- National Human Genome Center at Howard University
- Charles N. Rotimi
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-019-10967-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Type 2 diabetes (T2D) is prevalent in populations worldwide, however, mostly studied in European and mixed-ancestry populations. Here, the authors perform a genome-wide association study for T2D in over 5,000 sub-Saharan Africans and identify a locus, ZRANB3, that is specific for this population.
