Whole-brain propagating patterns in human resting-state brain activities

Abstract

Repetitive propagating activities in resting-state brain activities have been widely observed in various species and regions. Because they resemble the preceding brain activities during tasks, they are assumed to reflect past experiences embedded in neuronal circuits. “Whole-brain” propagating activities may also reflect a process that integrates information distributed over the entire brain, such as visual and motor information. Here we reveal whole-brain propagating activities from human resting-state magnetoencephalography (MEG) and electroencephalography (EEG) data. We simultaneously recorded the MEGs and EEGs and estimated the source currents from both measurements. Then using our recently proposed algorithm, we extracted repetitive spatiotemporal patterns from the source currents. The estimated patterns consisted of multiple frequency components, each of which transiently exhibited the frequency-specific resting-state networks (RSNs) of functional MRIs (fMRIs), such as the default mode and sensorimotor networks. A simulation test suggested that the spatiotemporal patterns reflected the phase alignment of the multiple frequency oscillators induced by the propagating activities along the anatomical connectivity. These results argue that whole-brain propagating activities transiently exhibited multiple RSNs in their multiple frequency components, suggesting that they reflected a process to integrate the information distributed over the frequencies and networks.

Keywords

• Resting-state
• Whole-brain propagating activity
• Spatiotemporal pattern
• Resting-state network
• Magnetoencephalography (MEG)
• Electroencephalography (EEG)