ESC Heart Failure (Dec 2021)

The genomics of heart failure: design and rationale of the HERMES consortium

  • R. Thomas Lumbers,
  • Sonia Shah,
  • Honghuang Lin,
  • Tomasz Czuba,
  • Albert Henry,
  • Daniel I. Swerdlow,
  • Anders Mälarstig,
  • Charlotte Andersson,
  • Niek Verweij,
  • Michael V. Holmes,
  • Johan Ärnlöv,
  • Per Svensson,
  • Harry Hemingway,
  • Neneh Sallah,
  • Peter Almgren,
  • Krishna G. Aragam,
  • Geraldine Asselin,
  • Joshua D. Backman,
  • Mary L. Biggs,
  • Heather L. Bloom,
  • Eric Boersma,
  • Jeffrey Brandimarto,
  • Michael R. Brown,
  • Hans‐Peter Brunner‐La Rocca,
  • David J. Carey,
  • Mark D. Chaffin,
  • Daniel I. Chasman,
  • Olympe Chazara,
  • Xing Chen,
  • Xu Chen,
  • Jonathan H. Chung,
  • William Chutkow,
  • John G.F. Cleland,
  • James P. Cook,
  • Simon deDenus,
  • Abbas Dehghan,
  • Graciela E. Delgado,
  • Spiros Denaxas,
  • Alexander S. Doney,
  • Marcus Dörr,
  • Samuel C. Dudley,
  • Gunnar Engström,
  • Tõnu Esko,
  • Ghazaleh Fatemifar,
  • Stephan B. Felix,
  • Chris Finan,
  • Ian Ford,
  • Francoise Fougerousse,
  • René Fouodjio,
  • Mohsen Ghanbari,
  • Sahar Ghasemi,
  • Vilmantas Giedraitis,
  • Franco Giulianini,
  • John S. Gottdiener,
  • Stefan Gross,
  • Daníel F. Guðbjartsson,
  • Hongsheng Gui,
  • Rebecca Gutmann,
  • Christopher M. Haggerty,
  • Pim van derHarst,
  • Åsa K. Hedman,
  • Anna Helgadottir,
  • Hans Hillege,
  • Craig L. Hyde,
  • Jaison Jacob,
  • J. Wouter Jukema,
  • Frederick Kamanu,
  • Isabella Kardys,
  • Maryam Kavousi,
  • Kay‐Tee Khaw,
  • Marcus E. Kleber,
  • Lars Køber,
  • Andrea Koekemoer,
  • Bill Kraus,
  • Karoline Kuchenbaecker,
  • Claudia Langenberg,
  • Lars Lind,
  • Cecilia M. Lindgren,
  • Barry London,
  • Luca A. Lotta,
  • Ruth C. Lovering,
  • Jian'an Luan,
  • Patrik Magnusson,
  • Anubha Mahajan,
  • Douglas Mann,
  • Kenneth B. Margulies,
  • Nicholas A. Marston,
  • Winfried März,
  • John J.V. McMurray,
  • Olle Melander,
  • Giorgio Melloni,
  • Ify R. Mordi,
  • Michael P. Morley,
  • Andrew D. Morris,
  • Andrew P. Morris,
  • Alanna C. Morrison,
  • Michael W. Nagle,
  • Christopher P. Nelson,
  • Christopher Newton‐Cheh,
  • Alexander Niessner,
  • Teemu Niiranen,
  • Christoph Nowak,
  • Michelle L. O'Donoghue,
  • Anjali T. Owens,
  • Colin N.A. Palmer,
  • Guillaume Paré,
  • Markus Perola,
  • Louis‐Philippe Lemieux Perreault,
  • Eliana Portilla‐Fernandez,
  • Bruce M. Psaty,
  • Kenneth M. Rice,
  • Paul M. Ridker,
  • Simon P.R. Romaine,
  • Carolina Roselli,
  • Jerome I. Rotter,
  • Christian T. Ruff,
  • Marc S. Sabatine,
  • Perttu Salo,
  • Veikko Salomaa,
  • Jessica vanSetten,
  • Alaa A. Shalaby,
  • Diane T. Smelser,
  • Nicholas L. Smith,
  • Kari Stefansson,
  • Steen Stender,
  • David J. Stott,
  • Garðar Sveinbjörnsson,
  • Mari‐Liis Tammesoo,
  • Jean‐Claude Tardif,
  • Kent D. Taylor,
  • Maris Teder‐Laving,
  • Alexander Teumer,
  • Guðmundur Thorgeirsson,
  • Unnur Thorsteinsdottir,
  • Christian Torp‐Pedersen,
  • Stella Trompet,
  • Danny Tuckwell,
  • Benoit Tyl,
  • Andre G. Uitterlinden,
  • Felix Vaura,
  • Abirami Veluchamy,
  • Peter M. Visscher,
  • Uwe Völker,
  • Adriaan A. Voors,
  • Xiaosong Wang,
  • Nicholas J. Wareham,
  • Peter E. Weeke,
  • Raul Weiss,
  • Harvey D. White,
  • Kerri L. Wiggins,
  • Heming Xing,
  • Jian Yang,
  • Yifan Yang,
  • Laura M. Yerges‐Armstrong,
  • Bing Yu,
  • Faiez Zannad,
  • Faye Zhao,
  • Regeneron Genetics Center,
  • Jemma B. Wilk,
  • Hilma Holm,
  • Naveed Sattar,
  • Steven A. Lubitz,
  • David E. Lanfear,
  • Svati Shah,
  • Michael E. Dunn,
  • Quinn S. Wells,
  • Folkert W. Asselbergs,
  • Aroon D. Hingorani,
  • Marie‐Pierre Dubé,
  • Nilesh J. Samani,
  • Chim C. Lang,
  • Thomas P. Cappola,
  • Patrick T. Ellinor,
  • Ramachandran S. Vasan,
  • J. Gustav Smith

DOI
https://doi.org/10.1002/ehf2.13517
Journal volume & issue
Vol. 8, no. 6
pp. 5531 – 5541

Abstract

Read online

Abstract Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

Keywords