COMPARATIVE ANTIHYPERLIPIDAEMIC EFFICACY OF TRACHYSPERMUM AMMI EXTRACTS IN ALBINO RABBITS

Abstract

Comparative antihyperlipidaemic efficacy of Trachyspermum ammi (L) Sprague (Ajowain) extracts in chloroform, methanol, petroleum ether and water was investigated in albino rabbits. Hyperlipidaemia was induced with butter fed ad libitum and oral intubation of cholesterol 400 mg/kg body weight. Simvastatin was used as a synthetic cholesterol lowering drug. The results suggested that chloroform and water extracts of T. ammi seed had no hypolipidaemic activity. However, methanol and petroleum ether extracts equivalent to its 2 g/kg body weight powder and Simvastatin (0.6 mg/kg body weight) were equally effective in treating hyperlipidaemia in albino rabbits. Moreover, petroleum ether extract appeared to be more potent than methanol extract on the basis of increasing the level of HDL-cholesterol and lowering the LDL-cholesterol more effectively than methanol extract. Petroleum ether extract reduced atherogenic index (total cholesterol/HDL-cholesterol) more effectively than methanol extract.

Keywords

• Lipid profile
• antihyperlipidaemia
• Trachyspermum ammi
• Simvastatin