A CDK-regulated chromatin segregase promoting chromosome replication

Erika Chacin; Priyanka Bansal; Karl-Uwe Reusswig; Luis M. Diaz-Santin; Pedro Ortega; Petra Vizjak; Belen Gómez-González; Felix Müller-Planitz; Andrés Aguilera; Boris Pfander; Alan C. M. Cheung; Christoph F. Kurat

doi:10.1038/s41467-021-25424-7

Nature Communications (Sep 2021)

A CDK-regulated chromatin segregase promoting chromosome replication

Erika Chacin,
Priyanka Bansal,
Karl-Uwe Reusswig,
Luis M. Diaz-Santin,
Pedro Ortega,
Petra Vizjak,
Belen Gómez-González,
Felix Müller-Planitz,
Andrés Aguilera,
Boris Pfander,
Alan C. M. Cheung,
Christoph F. Kurat

Affiliations

Erika Chacin: Molecular Biology Division, Biomedical Center Munich, Ludwig-Maximilians-Universität
Priyanka Bansal: Molecular Biology Division, Biomedical Center Munich, Ludwig-Maximilians-Universität
Karl-Uwe Reusswig: Max Planck Institute of Biochemistry, DNA Replication and Genome Integrity
Luis M. Diaz-Santin: Department of Structural and Molecular Biology, Institute of Structural and Molecular Biology, University College London
Pedro Ortega: Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, University of Seville-CSIC
Petra Vizjak: Molecular Biology Division, Biomedical Center Munich, Ludwig-Maximilians-Universität
Belen Gómez-González: Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, University of Seville-CSIC
Felix Müller-Planitz: Molecular Biology Division, Biomedical Center Munich, Ludwig-Maximilians-Universität
Andrés Aguilera: Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, University of Seville-CSIC
Boris Pfander: Max Planck Institute of Biochemistry, DNA Replication and Genome Integrity
Alan C. M. Cheung: Department of Structural and Molecular Biology, Institute of Structural and Molecular Biology, University College London
Christoph F. Kurat: Molecular Biology Division, Biomedical Center Munich, Ludwig-Maximilians-Universität

DOI: https://doi.org/10.1038/s41467-021-25424-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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How cells coordinate chromatin dynamics with the cell cycle machinery to promote genome duplication during S phase is still a matter of study. Here the authors reveal by in vitro reconstitution assays that the AAA + -ATPase containing Yta7 protein in S. cerevisiae promotes chromatin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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