Oral Candidiasis in Diabetes Patients

Abstract

Objective :1. Identification and isolation of candida spp in Patients with diabetes mellitus (DM). 2.To identify the relationship between some important parameters (age , gender , Glycosylated hemoglobin (HbA1c) ) Associated with diabetes and oral candidiasis . This study was performed in AL- Zahraa Teaching Hospital (Diabetic Center ) Wasit Governorate during the period from the first of December 2018 to the end of July 2019.The samples were collected from oral swabs ,then cultured on sabouraud dextrose agar (SDA) , examined under microscope to show hypha and pseudohypha of Candida spp and cultured on chrom agar for identifying the Candida spp. The molecular methods that used in this study were vitek 2 system and Polymerase chain reaction(PCR). The results showed that from 50 oral sample from Patients with diabetic mellitus showed 23 (46.6%) infected with candidiasis ,22 (95.6%) of them were C.albicans and 1(4.4 %) was other Candida spp (C.Dubliniensis) , while 27 (53.4%) were not infected. The Current study found a significant correlation between glycosylated hemoglobin and oral Candidiasis when the HbA1c was ranging from (6.5-8.5).

Keywords

• Oral candidiasis ,DM,SDA , HbA1c