Background: The extremely low loads (e.g., 32 and 25%, respectively, vs. baseline and/or pre-exercise for both protocols; all Ps 48% vs. baseline and pre-exercise; both Ps < 0.001). The degree of post-exercise IC improvements was significantly higher for ST-VLRE than for VLRE (P = 0.010 for condition × time interaction effect). Conclusions: These findings suggest that ST-VLRE can improve post-exercise IC effectively. Therefore, ST-VLRE may be an effective resistance exercise protocol for improving cognitive function.