PLoS ONE (Jan 2014)

Gated F-18 FDG PET for assessment of left ventricular volumes and ejection fraction using QGS and 4D-MSPECT in patients with heart failure: a comparison with cardiac MRI.

  • Yan Li,
  • Li Wang,
  • Shi-Hua Zhao,
  • Zuo-Xiang He,
  • Dao-Yu Wang,
  • Feng Guo,
  • Wei Fang,
  • Min-Fu Yang

DOI
https://doi.org/10.1371/journal.pone.0080227
Journal volume & issue
Vol. 9, no. 1
p. e80227

Abstract

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PurposeVentricular function is a powerful predictor of survival in patients with heart failure (HF). However, studies characterizing gated F-18 FDG PET for the assessment of the cardiac function are rare. The aim of this study was to prospectively compare gated F-18 FDG PET and cardiac MRI for the assessment of ventricular volume and ejection fraction (EF) in patients with HF.MethodsEighty-nine patients with diagnosed HF who underwent both gated F-18 FDG PET/CT and cardiac MRI within 3 days were included in the analysis. Left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), and EF were obtained from gated F-18 FDG PET/CT using the Quantitative Gated SPECT (QGS) and 4D-MSPECT software.ResultsLV EDV and LV ESV measured by QGS were significantly lower than those measured by cardiac MRI (both PConclusionDespite the observation that gated F-18 FDG PET/CT were well correlated with cardiac MRI for assessing LV function, variation was observed between the two imaging modalities, and so these imaging techniques should not be used interchangeably.