Crucial role of T cells in NAFLD-related disease: A review and prospect

Tianyu Mao; Tianyu Mao; Tianyu Mao; Rui Yang; Rui Yang; Rui Yang; Yi Luo; Yi Luo; Yi Luo; Kang He; Kang He; Kang He

doi:10.3389/fendo.2022.1051076

Frontiers in Endocrinology (Nov 2022)

Crucial role of T cells in NAFLD-related disease: A review and prospect

Tianyu Mao,
Tianyu Mao,
Tianyu Mao,
Rui Yang,
Rui Yang,
Rui Yang,
Yi Luo,
Yi Luo,
Yi Luo,
Kang He,
Kang He,
Kang He

Affiliations

Tianyu Mao: Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Tianyu Mao: Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, China
Tianyu Mao: Shanghai Institute of Transplantation, Shanghai, China
Rui Yang: Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Rui Yang: Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, China
Rui Yang: Shanghai Institute of Transplantation, Shanghai, China
Yi Luo: Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Yi Luo: Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, China
Yi Luo: Shanghai Institute of Transplantation, Shanghai, China
Kang He: Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Kang He: Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, China
Kang He: Shanghai Institute of Transplantation, Shanghai, China

DOI: https://doi.org/10.3389/fendo.2022.1051076
Journal volume & issue: Vol. 13

Abstract

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Nonalcoholic fatty liver disease (NAFLD) includes a series of hepatic manifestations, starting with liver steatosis and potentially evolving towards nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis or even hepatocellular carcinoma (HCC). Its incidence is increasing worldwide. Several factors including metabolic dysfunction, oxidative stress, lipotoxicity contribute to the liver inflammation. Several immune cell-mediated inflammatory processes are involved in NAFLD in which T cells play a crucial part in the progression of the disease. In this review, we focus on the role of different subsets of both conventional and unconventional T cells in pathogenesis of NAFLD. Factors regarding inflammation and potential therapeutic approaches targeting immune cells in NASH are also discussed.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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