Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation

Lvpiao Zheng; Ziling Luo; Biswaranjan Mohanty; Sana Amoozegar; Luke A. Johnson; Jerrold L. Vitek; Jing Wang

doi:10.1038/s41531-024-00797-w

npj Parkinson's Disease (Sep 2024)

Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation

Lvpiao Zheng,
Ziling Luo,
Biswaranjan Mohanty,
Sana Amoozegar,
Luke A. Johnson,
Jerrold L. Vitek,
Jing Wang

Affiliations

Lvpiao Zheng: Department of Neurology, University of Minnesota
Ziling Luo: Department of Neurology, University of Minnesota
Biswaranjan Mohanty: Department of Neurology, University of Minnesota
Sana Amoozegar: Department of Neurology, University of Minnesota
Luke A. Johnson: Department of Neurology, University of Minnesota
Jerrold L. Vitek: Department of Neurology, University of Minnesota
Jing Wang: Department of Neurology, University of Minnesota

DOI: https://doi.org/10.1038/s41531-024-00797-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 5

Abstract

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Abstract Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson’s disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.

Published in npj Parkinson's Disease

ISSN: 2373-8057 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.nature.com/npjparkd/

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