Cyclodextrins as Anti-inflammatory Agents: Basis, Drugs and Perspectives
Silvia Lucia Appleton,
Silvia Navarro-Orcajada,
Francisco Juan Martínez-Navarro,
Fabrizio Caldera,
José Manuel López-Nicolás,
Francesco Trotta,
Adrián Matencio
Affiliations
Silvia Lucia Appleton
Dip. Di Chimica, Università di Torino, via P. Giuria 7, 10125 Torino, Italy
Silvia Navarro-Orcajada
Departamento de Bioquímica y Biología Molecular A, Unidad Docente de Biología, Facultad de Veterinaria, Regional Campus of International Excellence “Campus Mare Nostrum”, Universidad de Murcia, 30100 Murcia, Spain
Francisco Juan Martínez-Navarro
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Fabrizio Caldera
Dip. Di Chimica, Università di Torino, via P. Giuria 7, 10125 Torino, Italy
José Manuel López-Nicolás
Departamento de Bioquímica y Biología Molecular A, Unidad Docente de Biología, Facultad de Veterinaria, Regional Campus of International Excellence “Campus Mare Nostrum”, Universidad de Murcia, 30100 Murcia, Spain
Francesco Trotta
Dip. Di Chimica, Università di Torino, via P. Giuria 7, 10125 Torino, Italy
Adrián Matencio
Dip. Di Chimica, Università di Torino, via P. Giuria 7, 10125 Torino, Italy
Inflammation is a biological response of the immune system to harmful stimuli. Importantly, inflammation is also a hallmark of several human diseases such as cancer or diabetes. Novel drugs to treat this response are constantly researched, but the formulation is usually forgotten. Cyclodextrins (CDs) are a well-known excipient for complexing and drug delivery. Anti-inflammatory drugs and bioactive compounds with similar activities have been favored from these CD processes. CDs also illustrate anti-inflammatory activity per se. This review tried to describe the capacities of CDs in this field, and is divided into two parts: Firstly, a short description of the inflammation disease (causes, symptoms, treatment) is explained; secondly, the effects of different CDs alone or forming inclusion complexes with drugs or bioactive compounds are discussed.
