SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP

Jocelyn E. Chau; Kimberly J. Vish; Titus J. Boggon; Amy L. Stiegler

doi:10.1038/s41467-022-32541-4

Nature Communications (Aug 2022)

SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP

Jocelyn E. Chau,
Kimberly J. Vish,
Titus J. Boggon,
Amy L. Stiegler

Affiliations

Jocelyn E. Chau: Department of Molecular Biophysics and Biochemistry, Yale University
Kimberly J. Vish: Department of Molecular Biophysics and Biochemistry, Yale University
Titus J. Boggon: Department of Molecular Biophysics and Biochemistry, Yale University
Amy L. Stiegler: Department of Pharmacology, Yale University

DOI: https://doi.org/10.1038/s41467-022-32541-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Inhibition of DLC1 RhoGAP by p120RasGAP allows for crosstalk between the Rho and Ras pathways. Here, Chau et al. present the co-crystal structure of DLC1 RhoGAP domain and p120RasGAP SH3 domain and probe the interaction with biochemical studies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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