Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing

Zhiqing Liu; Tianlong Wang; Jinhui Zhao; Lei Zhang; Yiping Luo; Yixing Chen; Xinhui Wu; Yaqi Liu; Aihemaitijiang Aierken; Dilixiati Duolikun; Hui Jiang; Xinyu Zhao; Chang Li; Yingchuan Li; Wentao Cao; Jianzhong Du; Longpo Zheng

Bioactive Materials (May 2025)

Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing

Zhiqing Liu,
Tianlong Wang,
Jinhui Zhao,
Lei Zhang,
Yiping Luo,
Yixing Chen,
Xinhui Wu,
Yaqi Liu,
Aihemaitijiang Aierken,
Dilixiati Duolikun,
Hui Jiang,
Xinyu Zhao,
Chang Li,
Yingchuan Li,
Wentao Cao,
Jianzhong Du,
Longpo Zheng

Affiliations

Zhiqing Liu: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Tianlong Wang: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Jinhui Zhao: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Lei Zhang: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Yiping Luo: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Yixing Chen: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Xinhui Wu: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Yaqi Liu: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Aihemaitijiang Aierken: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Dilixiati Duolikun: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Hui Jiang: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Xinyu Zhao: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Chang Li: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
Yingchuan Li: Department of Critical Care Medicine, School of Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China; Corresponding author. 301 Middle Yanchang Road, Jing'an District, Shanghai, 200072, China.
Wentao Cao: Department of Prosthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 201102, China; Corresponding authors. 166 Hechuan Road, Minhang District, Shanghai, 201100, China.
Jianzhong Du: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai, 201804, China; School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China; Corresponding author. 301 Middle Yanchang Road, Jing'an District, Shanghai, 200072, China.
Longpo Zheng: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Shanghai Trauma Emergency Center, Shanghai, 200072, China; Orthopedic Intelligent Minimally Invasive Diagnosis & Treatment Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Corresponding authors. 301 Middle Yanchang Road, Jing'an District, Shanghai, 200072, China.

Journal volume & issue: Vol. 47
pp. 266 – 282

Abstract

Read online

The pathological microenvironment in diabetic wounds is delineated by heightened inflammatory responses and persistent proinflammatory macrophage activity, which significantly hinders the wound healing process. Exogenous electrical stimulation (ES), by modulating the electric field distribution in wounds, has shown significant potential in treating inflammatory wounds. However, this approach relies on additional power sources and complex circuit designs. Here, a bionic neuro-immuno-regulatory (BNIR) system was proposed for reshaping the endogenous electric fields (EFs) through collecting ion flow. The BNIR system comprises microporous structure scaffolds and nanosheets, enabling swift biofluid collection and electrical signal transmission, with the ability to promote cell proliferation and migration and exhibit antioxidant properties. More importantly, the BNIR system induced the transition of M1 macrophages to M2 macrophages through neuro-immuno-regulatory. In diabetic rat skin wounds, the BNIR system significantly enhanced healing by simultaneously neuro-immuno-regulatory, promoting angiogenesis, scavenging ROS, and facilitating tissue remodeling. This work aims to advance the development of a bionic system for electrosensitive tissue repair.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

About the journal

Abstract

Keywords