EXPERIMENTAL MORPHOLOGICAL ASSESSMENT OF TOXIC LIVER DAMAGE IN ADMINISTRATION OF IMMUNODEPRESSANT MICOPHENOLATE MOFETYL

Abstract

Background. Drugs that have an immunosuppressive effect possess a wide spectrum of hepatotoxic effects. Aim of the study. To study the effect of the drug mycophenolate mofetyl (MMF) on the structure of liver tissue in rats. Material and methods. The morphology of the liver tissue of white, outbreed male rats was evaluated. MMF was administered at a daily dose of 40 mg/kg b.w. for 7, 14 days and 7 days followed by weekly drug cancellation. Results. No necrotic and fibrotic processes in the liver were detected in all terms and methods of experimental MMF exposure; the changes were limited to a weakly expressed intra-lobular small-focal lymphocytic-macrophage infiltration and fatty dystrophy of individual hepatocytes. Conclusion. Intragastric administration of MMF for 7 and 14 days can be performed for experimental modeling of immunodeficient conditions, not accompanied with the development of morphological signs of drug damage to the liver.

Keywords

• immunodeficiency
• modeling
• liver.
• live
• liver