Nature Communications (Nov 2021)
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control
- Jonathan M. Dreyfuss,
- Yixing Yuchi,
- Xuehong Dong,
- Vissarion Efthymiou,
- Hui Pan,
- Donald C. Simonson,
- Ashley Vernon,
- Florencia Halperin,
- Pratik Aryal,
- Anish Konkar,
- Yinong Sebastian,
- Brandon W. Higgs,
- Joseph Grimsby,
- Cristina M. Rondinone,
- Simon Kasif,
- Barbara B. Kahn,
- Kathleen Foster,
- Randy Seeley,
- Allison Goldfine,
- Vera Djordjilović,
- Mary Elizabeth Patti
Affiliations
- Jonathan M. Dreyfuss
- Bioinformatics and Biostatistics Core, Research Division, Joslin Diabetes Center
- Yixing Yuchi
- Harvard Medical School
- Xuehong Dong
- Harvard Medical School
- Vissarion Efthymiou
- Harvard Medical School
- Hui Pan
- Bioinformatics and Biostatistics Core, Research Division, Joslin Diabetes Center
- Donald C. Simonson
- Harvard Medical School
- Ashley Vernon
- Harvard Medical School
- Florencia Halperin
- Harvard Medical School
- Pratik Aryal
- Harvard Medical School
- Anish Konkar
- MedImmune
- Yinong Sebastian
- MedImmune
- Brandon W. Higgs
- MedImmune
- Joseph Grimsby
- MedImmune
- Cristina M. Rondinone
- MedImmune
- Simon Kasif
- Biomedical Engineering, Boston University
- Barbara B. Kahn
- Harvard Medical School
- Kathleen Foster
- Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center
- Randy Seeley
- Department of Surgery, University of Michigan
- Allison Goldfine
- Harvard Medical School
- Vera Djordjilović
- Department of Economics, Ca’ Foscari University of Venice
- Mary Elizabeth Patti
- Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-021-27289-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Factors underlying the effects of gastric bypass surgery on glucose homeostasis are incompletely understood. Here the authors developed and applied high-throughput mediation analysis to identify proteome/metabolome mediators of improved glucose homeostasis after to gastric bypass surgery, and report that improved glycemia was mediated by the growth hormone receptor.
