Is LP(a), as Predictor of Severity of Coronary Artery Disease?

Abstract

Background: Studies of the association between the plasma concentration of lipoprotein (a) and coronary heart disease (CHD) have reported apparently conflicting finding. Methods: The objective of the present study is to evaluate the association between serum levels of LP (a) and ischemic heart disease as well as other cardiovascular risk factors in a population – based study conducted on local cross sectional. LP (a) serum was measured in 142 patients with chronic stable angina who were under going clinically indicated coronary angiography. Lipid profilefasting blood glucose, anthropometric and clinical parameters were analyzed. Findings: LP (a) levels were significantly associated with numbers of coronary artery stenosis (CAD) in men, but no in women. Also, an direct association between mean levels of LP (a) and number of CAD in men younger than 55 years old inverse association in men older than 55years old were observed. Conclusion: Our multivariate analysis found that LP (a) was considered an independent predictor for severity of CHD in men, especially in younger individuals. Key words: Lipoprotein (a), Cardivascular risk factors, Ischemic heart disease.