The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases

Beijian Zhang; Hao Jiang; Zhen Dong; Aijun Sun; Junbo Ge

Genes and Diseases (Nov 2021)

The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases

Beijian Zhang,
Hao Jiang,
Zhen Dong,
Aijun Sun,
Junbo Ge

Affiliations

Beijian Zhang: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Shanghai Institute of Cardiovascular Diseases, Shanghai, 200003, PR China; NHC Key Laboratory of Viral Heart Diseases, Shanghai, 200032, PR China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, 200032, PR China
Hao Jiang: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Shanghai Institute of Cardiovascular Diseases, Shanghai, 200003, PR China; NHC Key Laboratory of Viral Heart Diseases, Shanghai, 200032, PR China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, 200032, PR China
Zhen Dong: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Shanghai Institute of Cardiovascular Diseases, Shanghai, 200003, PR China; NHC Key Laboratory of Viral Heart Diseases, Shanghai, 200032, PR China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, 200032, PR China
Aijun Sun: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Shanghai Institute of Cardiovascular Diseases, Shanghai, 200003, PR China; Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, PR China; NHC Key Laboratory of Viral Heart Diseases, Shanghai, 200032, PR China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, 200032, PR China; Corresponding author. Department of Cardiology, Zhongshan Hospital, Fudan University, No. 1609 Xietu Road, District Xuhui, Shanghai, 200025, PR China.
Junbo Ge: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Shanghai Institute of Cardiovascular Diseases, Shanghai, 200003, PR China; Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, PR China; NHC Key Laboratory of Viral Heart Diseases, Shanghai, 200032, PR China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, 200032, PR China; Corresponding author. Shanghai Institute of Cardiovascular Diseases, No. 1609 Xietu Road, District Xuhui, Shanghai, 200025, PR China.

Journal volume & issue: Vol. 8, no. 6
pp. 746 – 758

Abstract

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N6-methyladenosine (m6A) RNA methylation is an emerging area of epigenetics, which is a reversible and dynamic modification mediating by ‘writers’ (methylase, adding methyl groups, METTL3, METTL14, and WTAP), ‘erasers’ (demethylase, deleting methyl groups, FTO and ALKBH5), and ‘readers’ (YTHDF1-3, YTHDC1 and YTHDC2). Recent studies in human, animal models and cell levels have disclosed a critical role of m6A modification in regulating the homeostasis of metabolic processes and cardiovascular function. Evidence from these studies identify m6A as a candidate of biomarker and therapeutic target for metabolic abnormality and cardiovascular diseases (CVD). Comprehensive understanding of the complexity of m6A regulation in metabolic diseases and CVD will be helpful for us to understand the pathogenesis of CVD. In this review, we discuss the regulatory role of m6A in metabolic abnormality and CVD. We will emphasize the clinical relevance of m6A dysregulation in CVD.

Published in Genes and Diseases

ISSN: 2352-3042 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/genes-and-diseases/

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