Thermostability and in vivo performance of AAV9 in a film matrix

Trang Nguyen Kieu Doan; Matthew D. Le; Irnela Bajrovic; Lorne Celentano; Charles Krause; Haley Grooms Balyan; Abbie Svancarek; Angela Mote; Anna Tretiakova; R. Jude Samulski; Maria A. Croyle

doi:10.1038/s43856-022-00212-6

Communications Medicine (Nov 2022)

Thermostability and in vivo performance of AAV9 in a film matrix

Trang Nguyen Kieu Doan,
Matthew D. Le,
Irnela Bajrovic,
Lorne Celentano,
Charles Krause,
Haley Grooms Balyan,
Abbie Svancarek,
Angela Mote,
Anna Tretiakova,
R. Jude Samulski,
Maria A. Croyle

Affiliations

Trang Nguyen Kieu Doan: The University of Texas at Austin College of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery
Matthew D. Le: The University of Texas at Austin College of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery
Irnela Bajrovic: The University of Texas at Austin College of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery
Lorne Celentano: AskBio 20T.W. Alexander Drive
Charles Krause: AskBio 20T.W. Alexander Drive
Haley Grooms Balyan: AskBio 20T.W. Alexander Drive
Abbie Svancarek: AskBio 20T.W. Alexander Drive
Angela Mote: AskBio 20T.W. Alexander Drive
Anna Tretiakova: AskBio 20T.W. Alexander Drive
R. Jude Samulski: AskBio 20T.W. Alexander Drive
Maria A. Croyle: The University of Texas at Austin College of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery

DOI: https://doi.org/10.1038/s43856-022-00212-6
Journal volume & issue: Vol. 2, no. 1
pp. 1 – 14

Abstract

Read online

Doan et al. characterize and assess the stability of film matrix embedded Adeno-Associated Virus 9 (AAV9) vectors during storage and transport at ambient temperatures. High and low viscosity formulations of AAV9 stored at 25 °C maintain titer for 6 months.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

About the journal