MARKERS OF SYSTEMIC INFLAMMATION AND MATRIX METALLOPROTEINASE / TISSUE INHIBITOR OF METALLOPROTEINASES SYSTEM AT DIFFERENT STAGES OF CHRONIC HEART FAILURE

Abstract

Abstract. A comparative analysis of endotoxinemia grade, tumor necrosis factor α, C-reactive protein, sEselectin, matrix metalloproteinase-9 (MMP) and tissue inhibitor of metalloproteinases-4 (TIMP) levels was performed in a group of patients with chronic heart failure (CHF). An association has been shown between CHF progression and activation of systemic inflammation, like as with an imbalance in MMP/TIMP system. These alterations may represent a factor of structural disturbances in myocardial extracellular matrix, and promote a compartmental heart remodeling in this disorder.

Keywords

• chronic heart failure pathogenesis
• chronic systemic inflammation
• endotoxin
• proinflammatory cytokines
• matrix metalloproteinases