Balkan Medical Journal (Nov 2023)
The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye
- Fethi Gül,
- Umut Sabri Kasapoğlu,
- Mehmet Süleyman Sabaz,
- Pınar Ay,
- Burçin Doruk Oktay,
- Gülbahar Çalışkan,
- Nalan Demir,
- İsmet Sayan,
- Feyyaz Kabadayı,
- Gülsüm Altuntaş,
- Ayça Gümüş,
- Hülya Kırca,
- Deniz Şanlı,
- Fatma Acil,
- Andaç Dedeoğlu,
- Sedef Gülçin Ural,
- İrem Akın Şen,
- Eda Macit Aydın,
- Hakan Dayanır,
- Birgül Yelken,
- İlkay Ceylan,
- Osman Özcan Aydın,
- Güneş Eskidemir,
- Ahmet Aytekin,
- Melike Cengiz,
- Ülkü Arslan,
- Devrim Akdağ,
- Gülçin Hilal Alay,
- Esra Tekin,
- Volkan Yarar,
- Kemal Tolga Saracoğlu,
- Funda Gök,
- Volkan Alparslan,
- Verda Tuna,
- Murside Yıldız,
- Nimet Şenoğlu,
- Cenk Kıraklı,
- Süleyman Yıldırım,
- Kübra Saçar Kübüç,
- Ayşen Erer,
- Hamza Gültekin,
- Kezban Özmen Süner,
- Özge Kuzgun,
- Çağatay Erman Öztürk,
- Aydın Karahan,
- Okan Deveci,
- Mustafa Ay,
- Dilara Tüfek Öztan,
- Seda Banu Akıncı,
- Melahat Yalçın Solak,
- Süha Bozbay,
- Serhat Özçiftçi,
- Kamil Gönderen,
- Ahmet Oğuzhan Küçük,
- Berna Uyan,
- Gülseren Elay,
- Nazlıhan Boyacı,
- Mustafa Timurkaan,
- Ebru Karakoç,
- Lerzan Doğan,
- Erdem Yalçınkaya,
- Leyla Kazancıoğlu,
- Gül Erdal Dönmez,
- Barış Yılmaz,
- Dursun Fırat Ergül,
- Maruf Boran,
- Hüseyin Özkarakaş,
- Buğra Karakaş,
- Perihan Ergin Özcan,
- İlkay Anaklı,
- Mustafa Kemal Bayar,
- Didem Yüksel,
- Şükriye Akdağ,
- Özcan Pişkin,
- Sibel Temur,
- Selin Eyüpoğlu,
- Elvan Tekir Yılmaz,
- Gizem Zaim Avcı,
- Raziye Turan,
- Fatma Alkan Bayburt,
- Helin Şahintürk,
- Bülent Güçyetmez,
- Mustafa Muhlis Alparslan,
- Metin Yarıcı,
- Fatma Yıldırım,
- Abdulkadir Yektaş,
- Güçlü Yaman,
- Oktay Demirkıran,
- İsmail Cinel
Affiliations
- Fethi Gül
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Marmara University Faculty of Medicine, İstanbul, Türkiye
- Umut Sabri Kasapoğlu
- Clinic of Critical Care Medicine, Malatya Training and Research Hospital, Malatya, Türkiye
- Mehmet Süleyman Sabaz
- Clinic of Critical Care Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Türkiye
- Pınar Ay
- Department of Public Health, Marmara University Faculty of Medicine, İstanbul, Türkiye
- Burçin Doruk Oktay
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Marmara University Faculty of Medicine, İstanbul, Türkiye
- Gülbahar Çalışkan
- Department of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Bursa Faculty of Medicine, Bursa, Türkiye
- Nalan Demir
- Division of Critical Care Medicine, Clinic of Chest Diseases, University of Health Sciences Türkiye, Ankara City Hospital, Ankara, Türkiye
- İsmet Sayan
- Clinic of Critical Care Medicine, Sancaktepe Training and Research Hospital, İstanbul, Türkiye
- Feyyaz Kabadayı
- Clinic of Critical Care Medicine, Sancaktepe Training and Research Hospital, İstanbul, Türkiye
- Gülsüm Altuntaş
- Clinic of Critical Care Medicine, Elazığ City Hospital, Elazığ, Türkiye
- Ayça Gümüş
- Clinic of Critical Care Medicine, Antalya Kepez State Hospital, Antalya, Türkiye
- Hülya Kırca
- Clinic of Critical Care Medicine, Antalya Kepez State Hospital, Antalya, Türkiye
- Deniz Şanlı
- Clinic of Critical Care Medicine, Batman Training and Research Hospital, Batman, Türkiye
- Fatma Acil
- Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyabakır, Türkiye
- Andaç Dedeoğlu
- Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyabakır, Türkiye
- Sedef Gülçin Ural
- Clinic Critical Care Medicine, University of Health Sciences Türkiye, Erzurum City Hospital, Erzurum, Türkiye
- İrem Akın Şen
- Clinic Critical Care Medicine, University of Health Sciences Türkiye, Erzurum City Hospital, Erzurum, Türkiye
- Eda Macit Aydın
- Division of Critical Care Medicine, Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye
- Hakan Dayanır
- Division of Critical Care Medicine, Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye
- Birgül Yelken
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Türkiye
- İlkay Ceylan
- Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Bursa High Specialization Training and Research Hospital, Bursa, Türkiye
- Osman Özcan Aydın
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Türkiye
- Güneş Eskidemir
- Clinic of Critical Care Medicine, Gaziosmanpaşa Training and Research Hospital, İstanbul, Türkiye
- Ahmet Aytekin
- Clinic of Anesthesiology and Reanimation, Göztepe Prof. Dr. Süleyman Yalçın City Hospital, İstanbul, Türkiye
- Melike Cengiz
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Akdeniz University Faculty of Medicine, Antalya, Türkiye
- Ülkü Arslan
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Akdeniz University Faculty of Medicine, Antalya, Türkiye
- Devrim Akdağ
- Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Adana City Hospital, Adana, Türkiye
- Gülçin Hilal Alay
- Department of Anesthesiology and Reanimation, University of Health Sciences Türkiye, İstanbul Başakşehir Çam and Sakura City Hospital, İstanbul, Türkiye
- Esra Tekin
- Clinic of Critical Care Medicine, Denizli State Hospital, Denizli, Türkiye
- Volkan Yarar
- Clinic of Critical Care Medicine, Balıkesir Atatürk City Hospital, Balıkesir, Türkiye
- Kemal Tolga Saracoğlu
- Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Kartal Lütfi Kırdar Training and Research Hospital, İstanbul, Türkiye
- Funda Gök
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Necmettin Erbakan University Faculty of Medicine, Konya, Türkiye
- Volkan Alparslan
- Clinic of Critical Care Medicine, Hatay Training and Research Hospital, Hatay, Türkiye
- Verda Tuna
- Clinic of Critical Care Medicine, Adıyaman Training and Research Hospital, Adıyaman, Türkiye
- Murside Yıldız
- Clinic of Critical Care Medicine, Ağrı Training and Research Hospital, Ağrı, Türkiye
- Nimet Şenoğlu
- Division of Critical Care Medicine, Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Tepecik Training and Research Hospital, İzmir, Türkiye
- Cenk Kıraklı
- Department of Critical Care Medicine, University of Health Sciences Türkiye, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, İzmir, Türkiye
- Süleyman Yıldırım
- Department of Critical Care Medicine, University of Health Sciences Türkiye, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, İzmir, Türkiye
- Kübra Saçar Kübüç
- Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Van Training and Research Hospital, Van, Türkiye
- Ayşen Erer
- Clinic of Critical Care Medicine, Tekirdağ İsmail Fehmi Cumalioğlu City Hospital, Tekirdag, Türkiye
- Hamza Gültekin
- Clinic of Critical Care Medicine, Şırnak State Hospital, Şırnak, Türkiye
- Kezban Özmen Süner
- Clinic of Critical Care Medicine, Sakarya Training and Research Hospital, Sakarya, Türkiye
- Özge Kuzgun
- Clinic of Critical Care Medicine, Sakarya Training and Research Hospital, Sakarya, Türkiye
- Çağatay Erman Öztürk
- Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Samsun Training and Research Hospital, Samsun, Türkiye
- Aydın Karahan
- Clinic of Critical Care Medicine, Mersin City Hospital, Mersin, Türkiye
- Okan Deveci
- Clinic of Critical Care Medicine, Mersin City Hospital, Mersin, Türkiye
- Mustafa Ay
- Clinic of Anesthesiology and Reanimation, Antalya Training and Research Hospital, Antalya, Türkiye
- Dilara Tüfek Öztan
- Clinic of Anesthesiology and Reanimation, Antalya Training and Research Hospital, Antalya, Türkiye
- Seda Banu Akıncı
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Ankara, Türkiye
- Melahat Yalçın Solak
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Ankara, Türkiye
- Süha Bozbay
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hitit University Faculty of Medicine, Çorum, Türkiye
- Serhat Özçiftçi
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hitit University Faculty of Medicine, Çorum, Türkiye
- Kamil Gönderen
- Department of Critical Care Medicine, İzmir Katip Çelebi University, Atatürk Training and Research Hospital, İzmir, Türkiye
- Ahmet Oğuzhan Küçük
- Division of Critical Care Medicine, Department of Chest Diseases, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye
- Berna Uyan
- Department Critical Care Medicine, Gaziantep Şehit Kamil State Hospital, Gaziantep, Türkiye
- Gülseren Elay
- Division of Critical Care Medicine, Department of Internal Medicine, Gaziantep University Faculty of Medicine, Gaziantep, Türkiye
- Nazlıhan Boyacı
- Division of Critical Care Medicine, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Türkiye
- Mustafa Timurkaan
- Clinic of Critical Care Medicine, Elazığ City Hospital, Elazığ, Türkiye
- Ebru Karakoç
- Department of Critical Care Medicine, Çankırı State Hospital, Çankırı, Türkiye
- Lerzan Doğan
- Department of Critical Care Medicine, Altunizade Acıbadem Hospital, İstanbul, Türkiye
- Erdem Yalçınkaya
- Department of Critical Care Medicine, Sivas Numune Hospital, Sivas, Türkiye
- Leyla Kazancıoğlu
- Department of Anesthesiology and Reanimation, Recep Tayyip Erdoğan University Faculty of Medicine, Rize, Türkiye
- Gül Erdal Dönmez
- Department of Critical Care Medicine, University of Health Sciences Türkiye, İstanbul Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Türkiye
- Barış Yılmaz
- Department of Critical Care Medicine, University of Health Sciences Türkiye, İstanbul Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Türkiye
- Dursun Fırat Ergül
- Department of Critical Care Medicine, Amasya University Sabuncuoğlu Şerafettin Training and Research Hospital, Amasya, Türkiye
- Maruf Boran
- Department of Critical Care Medicine, Amasya University Sabuncuoğlu Şerafettin Training and Research Hospital, Amasya, Türkiye
- Hüseyin Özkarakaş
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, University of Health Sciences Türkiye, İzmir Bozyaka Training and Research Hospital, İzmir, Türkiye
- Buğra Karakaş
- Clinic of Critical Care Medicine, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Türkiye
- Perihan Ergin Özcan
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, İstanbul University Capa Faculty of Medicine, İstanbul, Türkiye
- İlkay Anaklı
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, İstanbul University Capa Faculty of Medicine, İstanbul, Türkiye
- Mustafa Kemal Bayar
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Ankara University Faculty of Medicine, Ankara, Türkiye
- Didem Yüksel
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Ankara University Faculty of Medicine, Ankara, Türkiye
- Şükriye Akdağ
- Department of Anesthesiology and Reanimation, Yasar Eryılmaz Ağrı Doğubeyazıt State Hospital, Ağrı, Türkiye
- Özcan Pişkin
- Department of Anesthesiology and Reanimation, Zonguldak Bülent Ecevit University Faculty of Medicine, Zonguldak, Türkiye
- Sibel Temur
- Department of Anesthesiology and Reanimation, Yeditepe University Faculty of Medicine, İstanbul, Türkiye
- Selin Eyüpoğlu
- Clinic of Critical Care Medicine, Giresun Training and Research Hospital, Giresun, Türkiye
- Elvan Tekir Yılmaz
- Clinic of Anesthesiology and Reanimation, Giresun University Faculty of Medicine, Giresun Training and Research Hospital, Giresun, Türkiye
- Gizem Zaim Avcı
- Clinic of Anesthesiology and Reanimation, Giresun Prof. Dr. İlhan Özdemir State Hospital, Giresun Türkiye
- Raziye Turan
- Clinic of Anesthesiology and Reanimation, Giresun Prof. Dr. İlhan Özdemir State Hospital, Giresun Türkiye
- Fatma Alkan Bayburt
- Clinic of Anesthesiology and Reanimation, Giresun Prof. Dr. İlhan Özdemir State Hospital, Giresun Türkiye
- Helin Şahintürk
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Başkent University Faculty of Medicine, Ankara, Türkiye
- Bülent Güçyetmez
- Department of Anesthesiology and Reanimation, Acıbadem Mehmet Ali Aydınlar University Faculty of Medicine, İstanbul, Türkiye
- Mustafa Muhlis Alparslan
- Clinic of Anesthesiology and Reanimation, Aksaray University Training and Research Hospital, Aksaray, Türkiye
- Metin Yarıcı
- Department of Critical Care Medicine, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye
- Fatma Yıldırım
- Department of Chest Diseases, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye
- Abdulkadir Yektaş
- Department of Anesthesiology and Reanimation, Siirt University Faculty of Medicine, Siirt, Türkiye
- Güçlü Yaman
- https://gucluyaman.com/tr/
- Oktay Demirkıran
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, İstanbul, Türkiye
- İsmail Cinel
- Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Marmara University Faculty of Medicine, İstanbul, Türkiye
- DOI
- https://doi.org/10.4274/balkanmedj.galenos.2023.2023-6-90
- Journal volume & issue
-
Vol. 40,
no. 6
pp. 435 – 444
Abstract
Background:Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear.Aims:To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19.Study Design:Multicenter prospective observational clinical study.Methods:This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged ≥ 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated.Results:As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 ± 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores (p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) (p = 0.004).Conclusion:Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients.
