Age-Related Decline of Sensorimotor Integration Influences Resting-State Functional Brain Connectivity

Abstract

Age-related decline in sensorimotor integration involves both peripheral and central components related to proprioception and kinesthesia. To explore the role of cortical motor networks, we investigated the association between resting-state functional connectivity and a gap-detection angle measured during an arm-reaching task. Four region pairs, namely the left primary sensory area with the left primary motor area (S1left–M1left), the left supplementary motor area with M1left (SMAleft–M1left), the left pre-supplementary motor area with SMAleft (preSMAleft–SMAleft), and the right pre-supplementary motor area with the right premotor area (preSMAright–PMdright), showed significant age-by-gap detection ability interactions in connectivity in the form of opposite-sign correlations with gap detection ability between younger and older participants. Morphometry and tractography analyses did not reveal corresponding structural effects. These results suggest that the impact of aging on sensorimotor integration at the cortical level may be tracked by resting-state brain activity and is primarily functional, rather than structural. From the observation of opposite-sign correlations, we hypothesize that in aging, a “low-level” motor system may hyper-engage unsuccessfully, its dysfunction possibly being compensated by a “high-level” motor system, wherein stronger connectivity predicts higher gap-detection performance. This hypothesis should be tested in future neuroimaging and clinical studies.

Keywords

• arm-reaching task
• functional connectivity
• kinesthesia
• motor coordination
• normal aging
• proprioception