Nature Communications (Jun 2021)
Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
- Michael Lacy,
- Christina Bürger,
- Annelie Shami,
- Maiwand Ahmadsei,
- Holger Winkels,
- Katrin Nitz,
- Claudia M. van Tiel,
- Tom T. P. Seijkens,
- Pascal J. H. Kusters,
- Ela Karshovka,
- Koen H. M. Prange,
- Yuting Wu,
- Sanne L. N. Brouns,
- Sigrid Unterlugauer,
- Marijke J. E. Kuijpers,
- Myrthe E. Reiche,
- Sabine Steffens,
- Andreas Edsfeldt,
- Remco T. A. Megens,
- Johan W. M. Heemskerk,
- Isabel Goncalves,
- Christian Weber,
- Norbert Gerdes,
- Dorothee Atzler,
- Esther Lutgens
Affiliations
- Michael Lacy
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Christina Bürger
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Annelie Shami
- Department of Clinical Sciences Malmö, Lund University, Clinical Research Center
- Maiwand Ahmadsei
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Holger Winkels
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Katrin Nitz
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Claudia M. van Tiel
- Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam
- Tom T. P. Seijkens
- Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam
- Pascal J. H. Kusters
- Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam
- Ela Karshovka
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Koen H. M. Prange
- Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam
- Yuting Wu
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Sanne L. N. Brouns
- Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University
- Sigrid Unterlugauer
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Marijke J. E. Kuijpers
- Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University
- Myrthe E. Reiche
- Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam
- Sabine Steffens
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Andreas Edsfeldt
- Department of Clinical Sciences Malmö, Lund University, Clinical Research Center
- Remco T. A. Megens
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Johan W. M. Heemskerk
- Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University
- Isabel Goncalves
- Department of Clinical Sciences Malmö, Lund University, Clinical Research Center
- Christian Weber
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Norbert Gerdes
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Dorothee Atzler
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- Esther Lutgens
- Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität
- DOI
- https://doi.org/10.1038/s41467-021-23909-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell-specific functions of the most relevant CD40L-expressing cell types in atherosclerosis. Deficiency of T cell-derived CD40L reduces and stabilizes plaques through impaired Th1 polarization while platelet-derived CD40L ameliorates atherothrombosis.
