Hepatocellular Carcinoma Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE): Outcome Analysis Using a Model Based On Pre-Treatment CT Texture Features
Marcello Andrea Tipaldi,
Edoardo Ronconi,
Elena Lucertini,
Miltiadis Krokidis,
Marta Zerunian,
Tiziano Polidori,
Paola Begini,
Massimo Marignani,
Federica Mazzuca,
Damiano Caruso,
Michele Rossi,
Andrea Laghi
Affiliations
Marcello Andrea Tipaldi
Department of Surgical and Medical Sciences and Translational Medicine, Sapienza-University of Rome, 00189 Rome, Italy
Edoardo Ronconi
Department of Radiology, Sant’Andrea University of Hospital La Sapienza, 00189 Rome, Italy
Elena Lucertini
Department of Radiology, Sant’Andrea University of Hospital La Sapienza, 00189 Rome, Italy
Miltiadis Krokidis
Department of Radiology, Areteion Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece
Marta Zerunian
Department of Surgical and Medical Sciences and Translational Medicine, Sapienza-University of Rome, 00189 Rome, Italy
Tiziano Polidori
Department of Radiology, Sant’Andrea University of Hospital La Sapienza, 00189 Rome, Italy
Paola Begini
Department of Liver Diseases Section, AOU Sant’Andrea Hospital, University of Hospital La Sapienza, 00189 Rome, Italy
Massimo Marignani
Department of Liver Diseases Section, AOU Sant’Andrea Hospital, University of Hospital La Sapienza, 00189 Rome, Italy
Federica Mazzuca
Department of Clinical and Molecular Oncology-Sapienza, University of Rome, Sant’Andrea University Hospital, via di Grottarossa 1035, 00189 Rome, Italy
Damiano Caruso
Department of Radiological Sciences, Oncological and Pathological Sciences, University of Rome Sapienza, Sant’Andrea University Hospital, 00189 Rome, Italy
Michele Rossi
Department of Surgical and Medical Sciences and Translational Medicine, Sapienza-University of Rome, 00189 Rome, Italy
Andrea Laghi
Department of Surgical and Medical Sciences and Translational Medicine, Sapienza-University of Rome, 00189 Rome, Italy
(1) Introduction and Aim: The aim of this study is to investigate the prognostic value, in terms of response and survival, of CT-based radiomics features for patients with HCC undergoing drug-eluting beads transarterial chemoembolization (DEB-TACE). (2) Materials and Methods: Pre-treatment CT examinations of 50 patients with HCC, treated with DEB-TACE were manually segmented to obtain the tumor volumetric region of interest, extracting radiomics features with TexRAD. Response to therapy evaluation was performed basing on post-procedural CT examination compared to pre-procedural CT, using modified RECIST criteria for HCC. The prognostic value of texture analysis was evaluated, investigating the correlation between radiomics features, response to therapy and overall survival. Three models based on texture and clinical variables and a combination of them were finally built; (3) Results: Entropy, skewness, MPP and kurtosis showed a significant correlation with complete response (CR) to TACE (all p p p < 0.0001). (4) Conclusion: Texture analysis based on pre-treatment CT examination is associated with response to therapy and survival in patients with HCC undergoing DEB-TACE, especially if combined with clinical data.
