Nature Communications (Feb 2023)
Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models
- Björn Corleis,
- Donata Hoffmann,
- Susanne Rauch,
- Charlie Fricke,
- Nicole Roth,
- Janina Gergen,
- Kristina Kovacikova,
- Kore Schlottau,
- Nico Joel Halwe,
- Lorenz Ulrich,
- Jacob Schön,
- Kerstin Wernike,
- Marek Widera,
- Sandra Ciesek,
- Stefan O. Mueller,
- Thomas C. Mettenleiter,
- Domenico Maione,
- Benjamin Petsch,
- Martin Beer,
- Anca Dorhoi
Affiliations
- Björn Corleis
- Institute of Immunology, Friedrich-Loeffler-Institut
- Donata Hoffmann
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut
- Susanne Rauch
- CureVac SE
- Charlie Fricke
- Institute of Immunology, Friedrich-Loeffler-Institut
- Nicole Roth
- CureVac SE
- Janina Gergen
- CureVac SE
- Kristina Kovacikova
- CureVac SE
- Kore Schlottau
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut
- Nico Joel Halwe
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut
- Lorenz Ulrich
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut
- Jacob Schön
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut
- Kerstin Wernike
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut
- Marek Widera
- Institute for Med. Virology, University Hospital Frankfurt, Goethe University Frankfurt
- Sandra Ciesek
- Institute for Med. Virology, University Hospital Frankfurt, Goethe University Frankfurt
- Stefan O. Mueller
- CureVac SE
- Thomas C. Mettenleiter
- Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health
- Domenico Maione
- GSK
- Benjamin Petsch
- CureVac SE
- Martin Beer
- Institute of Diagnostic Virology, Friedrich-Loeffler-Institut
- Anca Dorhoi
- Institute of Immunology, Friedrich-Loeffler-Institut
- DOI
- https://doi.org/10.1038/s41467-023-36110-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 8
Abstract
Here the authors show efficacy of a low-dose, unmodified, bivalent mRNA vaccine against SARS-CoV-2 variants in two female rodent models and find that combination of mRNA encoding Beta and Delta Spike sequences induces broadly neutralizing antibodies and robust T-cell responses.
