High expression of HMBOX1 contributes to poor prognosis of gastric cancer by promoting cell proliferation and migration

Nannan Diao; Yuzheng Li; Jinling Yang; Chengjuan Jin; Xiaohui Meng; Wenlin Jiao; Jinbo Feng; Zhenping Liu; Nan Lu

Biomedicine & Pharmacotherapy (Jul 2019)

High expression of HMBOX1 contributes to poor prognosis of gastric cancer by promoting cell proliferation and migration

Nannan Diao,
Yuzheng Li,
Jinling Yang,
Chengjuan Jin,
Xiaohui Meng,
Wenlin Jiao,
Jinbo Feng,
Zhenping Liu,
Nan Lu

Affiliations

Nannan Diao: Institute of Diagnostics, School of Medicine, Shandong University, Ji’nan, Shandong, China; Department of Clinical Laboratory, Shanghai Skin Disease Hospital, Shanghai, China
Yuzheng Li: Institute of Yantai, China Agricultural University, Beijing, China
Jinling Yang: Institute of Diagnostics, School of Medicine, Shandong University, Ji’nan, Shandong, China
Chengjuan Jin: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji’nan, Shandong, China; Key Laboratory of Gynecologic Oncology of Shandong Province, Qilu Hospital, Shandong University, Ji’nan, Shandong, China
Xiaohui Meng: Institute of Diagnostics, School of Medicine, Shandong University, Ji’nan, Shandong, China
Wenlin Jiao: National Research Center for Assisted Reproductive Technology and Reproduction Genetics, Ji’nan, Shandong, China
Jinbo Feng: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji’nan, Shandong, China; Key Laboratory of Gynecologic Oncology of Shandong Province, Qilu Hospital, Shandong University, Ji’nan, Shandong, China
Zhenping Liu: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji’nan, Shandong, China; Key Laboratory of Gynecologic Oncology of Shandong Province, Qilu Hospital, Shandong University, Ji’nan, Shandong, China
Nan Lu: Institute of Diagnostics, School of Medicine, Shandong University, Ji’nan, Shandong, China; Corresponding author.

Journal volume & issue: Vol. 115

Abstract

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Homeobox-containing 1 (HMBOX1) has been reported to be associated with biological characteristics of some tumors, but its roles in gastric cancer have never been reported. In the present study, we found that HMBOX1 expression was significantly upregulated in gastric cancer tissues and cell lines and correlated with the TNM stage, lymph-node metastatic and the overall survival (OS) of patients of gastric cancer. The overexpression of HMBOX1 in gastric cancer cells enhanced cell proliferation by accelerating cell cycle, induced cell migration. In contrast, silencing HMBOX1 inhibited these processes. And the expression of HMBOX1 was related with the expression of vascular endothelial growth factor receptor (VEGFR), transforming growth factor-β (TGF-β) and CD133. What’s more, we found that the expression of CD133 had a significantly positive correlation with HMBOX1 in gastric cancer tissues, and the co-expression of HMBOX1 and CD133 was significantly correlated with poor prognosis of gastric cancer patients, especially for patients at III and IV stage. In conclusion, HMBOX1 was upregulated in gastric cancer and correlated with gastric cancer cell proliferation and migration. Moreover, HMBOX1 combined CD133 might be useful to predict survival of patients with advanced gastric cancer.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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