Ferroptosis and Its Potential Role in Lung Cancer: Updated Evidence from Pathogenesis to Therapy

Abstract

Kang Chen,1 Song Zhang,2 Jinghua Jiao,3 Shan Zhao4 1Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China; 2China Medical University, Shenyang, Liaoning, People’s Republic of China; 3Department of Anesthesiology, Central Hospital, Shenyang Medical College, Shenyang, Liaoning, People’s Republic of China; 4Department of Rheumatic Immunology, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of ChinaCorrespondence: Jinghua Jiao; Shan Zhao Email [email protected]; [email protected]: Lung cancer is characterized by high morbidity and mortality rates, and its occurrence is associated with many types of cell death. As a new form of regulated cell death, ferroptosis is an iron- dependent pattern of cell death and characterized by lethal accumulation of lipid-based reactive oxygen species (ROS), which is different from apoptosis, necrosis and autophagy at both the morphological and biochemical levels. It plays an important role in the development of lung cancer and induction of ferroptosis in lung cancer cells has become a new strategy for anti- lung cancer treatment. However, a few reviews summarized ferroptosis and its role in lung cancer has not been elucidated, and the precise mechanism of ferroptosis modeling lung cancer has not yet been revealed till date. Herein, we review the latest literature on the process of ferroptosis regarding lung cancer, including basic molecular or biology mechanistic studies both in vivo and in vitro, as well as human studies with a more translational or clinical approach. This review provides a practical, concise and updated outline on the mechanisms and therapeutic strategies in lung cancer with ferroptosis alterations. Looking ahead, further studies are required to uncover the possible modulatory relationship between ferroptosis and lung cancer.Keywords: programmed cell death, ferroptosis, biochemical process, lung cancer

Keywords

• programmed cell death
• ferroptosis
• biochemical process
• lung cancer