Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice

Ming-Yi Chou; Xuhui Cao; Kuan-Chu Hou; Meng-Han Tsai; Chih-Yu Lee; Meng-Fai Kuo; Vin-Cent Wu; Hsin-Yi Huang; Schahram Akbarian; Sheng-Kai Chang; Chung-Yi Hu; Shu-Wha Lin; Hsien-Sung Huang

doi:10.1038/s42003-023-04655-y

Communications Biology (Mar 2023)

Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice

Ming-Yi Chou,
Xuhui Cao,
Kuan-Chu Hou,
Meng-Han Tsai,
Chih-Yu Lee,
Meng-Fai Kuo,
Vin-Cent Wu,
Hsin-Yi Huang,
Schahram Akbarian,
Sheng-Kai Chang,
Chung-Yi Hu,
Shu-Wha Lin,
Hsien-Sung Huang

Affiliations

Ming-Yi Chou: Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University
Xuhui Cao: Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University
Kuan-Chu Hou: Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University
Meng-Han Tsai: Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University
Chih-Yu Lee: Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University
Meng-Fai Kuo: Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine
Vin-Cent Wu: Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University
Hsin-Yi Huang: Department of Pathology, National Taiwan University Hospital and College of Medicine, National Taiwan University
Schahram Akbarian: Department of Psychiatry, Icahn School of Medicine at Mount Sinai
Sheng-Kai Chang: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University
Chung-Yi Hu: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University
Shu-Wha Lin: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University
Hsien-Sung Huang: Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University

DOI: https://doi.org/10.1038/s42003-023-04655-y
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 12

Abstract

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Knockout of Mir125b-2 in mice leads to defects in hippocampus-related behaviors and affects hippocampal expression of Grin2a and NMDAR-mediated currents.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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