Physostigmine as an antinociceptive agent: a possible way to improve the safety of anesthesia

Abstract

Search for new safe analgesics is an urgent task that will increase the safety and efficiency of anesthesia. The aim of this study was to investigate the analgesic effect of intrathecally administered physostigmine. Antinociceptive effect was evaluated by using the method «plantar» stimulation. Administered intrathecally physostigmine caused analgesic action in the early postoperative period. Efficiency of physostigmine may be due to the influence on cholinergic links of afferent gate control system at spinal level.

Keywords

• физостигмин
• анальгезия
• контроль афферентного входа
• холинергическая передача
• physostigmine
• analgesia
• afferent gate control
• cholinergic transmission