Journal of Enzyme Inhibition and Medicinal Chemistry (Jan 2019)

Design and application of oral colon administration system

  • Hao Cheng,
  • Shiyu Huang,
  • Gangliang Huang

DOI
https://doi.org/10.1080/14756366.2019.1655406
Journal volume & issue
Vol. 34, no. 1
pp. 1590 – 1596

Abstract

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Oral colon administration system has become a new method to treat intestinal diseases. The implementation of colon drug delivery system is restricted by many aspects, including physical and chemical properties, drug delivery mode, gastrointestinal physiological factors, and so on. Delivery methods to overcome these challenges revolve around the mechanisms of drug delivery, including the use of rational dosage forms to avoid the complex pH environment, and the prevention of drug release and absorption in the upper digestive tract.

Keywords