P333: SUBCLONAL AND CLONAL VARIANTS IN TP53 AND KRAS COMBINED WITH POOR TREATMENT RESPONSE IDENTIFY A SUBGROUP OF ULTRA-HIGH-RISK PATIENTS OF PEDIATRIC T-LYMPHOBLASTIC LEUKEMIA (T-ALL)

• Tamara Kempter,
• Paulina Richter-Pechanska,
• Katarzyna Michel,
• Tobias Rausch,
• Büşra Erarslan-Uysal,
• Cornelia Eckert,
• Martin Zimmermann,
• Martin Stanulla,
• Martin Schrappe,
• Gunnar Cario,
• Renate Kirschner-Schwabe,
• Stefan Koehrer,
• Jan Korbel,
• Joachim Kunz,
• Andreas E Kulozik

Affiliations

Tamara Kempter

1 University of Heidelberg, Department of Pediatric Oncology, Hematology, and Immunology and Hopp Children’s Cancer Center Heidelberg (KiTZ), University of Heidelberg, Germany, Heidelberg, Germany

Paulina Richter-Pechanska

1 University of Heidelberg, Department of Pediatric Oncology, Hematology, and Immunology and Hopp Children’s Cancer Center Heidelberg (KiTZ), University of Heidelberg, Germany, Heidelberg, Germany

Katarzyna Michel

1 University of Heidelberg, Department of Pediatric Oncology, Hematology, and Immunology and Hopp Children’s Cancer Center Heidelberg (KiTZ), University of Heidelberg, Germany, Heidelberg, Germany

Tobias Rausch

2 University of Heidelberg, Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

Büşra Erarslan-Uysal

1 University of Heidelberg, Department of Pediatric Oncology, Hematology, and Immunology and Hopp Children’s Cancer Center Heidelberg (KiTZ), University of Heidelberg, Germany, Heidelberg, Germany

Cornelia Eckert

4 Charité University School of Medicine Berlin, Department of Pediatric Oncology/Hematology, Berlin, Germany

Martin Zimmermann

5 Hannover Medical School, Pediatric Hematology and Oncology, Hannover, Germany

Martin Stanulla

5 Hannover Medical School, Pediatric Hematology and Oncology, Hannover, Germany

Martin Schrappe

6 University Hospital Schleswig-Holstein, Department of Pediatrics, Campus Kiel, Kiel, Germany

Gunnar Cario

6 University Hospital Schleswig-Holstein, Department of Pediatrics, Campus Kiel, Kiel, Germany

Renate Kirschner-Schwabe

4 Charité University School of Medicine Berlin, Department of Pediatric Oncology/Hematology, Berlin, Germany

Stefan Koehrer

7 Labdia Labordiagnostik, Vienna, Austria

Jan Korbel

2 University of Heidelberg, Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

Joachim Kunz

1 University of Heidelberg, Department of Pediatric Oncology, Hematology, and Immunology and Hopp Children’s Cancer Center Heidelberg (KiTZ), University of Heidelberg, Germany, Heidelberg, Germany

Andreas E Kulozik

1 University of Heidelberg, Department of Pediatric Oncology, Hematology, and Immunology and Hopp Children’s Cancer Center Heidelberg (KiTZ), University of Heidelberg, Germany, Heidelberg, Germany