Effect of 8 week continuous training with resveratrol supplementation on anti-oxidative markers (SOD and GPX) and oxidative marker (MDA) of hepatocyte tissue in streptozotocin-diabetic male rats

Abstract

Introduction Diabetes mellitus is a serious and complex chronic disease and is a major contributor to the health problems around the world. The purpose of this study was to compare the simultaneous effect of resveratrol supplementation and continuous training on anti-oxidative markers (SOD and GPX) and hepatocytic oxidative marker (MDA) in streptozotocin-diabetic male Wistar rats. Materials and Methods 60 wistar rats including healthy control groups, diabetic, diabetic saline, resveratrol supplement, continuation training and complementary resveratrol + continuation training were evaluated. (SOD and GPX) and (MDA) were evaluated by ELISA kit. One-way analysis of variance and Tukey's post hoc test were used for data analysis. The significance level was considered 0.05 and SPSS 23 software was used. Results The mean concentration of SOD and GPX in diabetic and diabetic saline patients compared to other groups was significantly lower (P≥0/001) and MDA concentration in diabetic and diabetic saline patients compared to other groups was significantly higher (P ≥ 0/001). continuous training and resveratrol alone or in particular resveratrol intervention with continuous training significantly increased the mean concentration of SOD and GPX concentration (P≥0/001)and A significant decrease was observed in the mean concentration of MDA (P≥0/001). Conclusion The use of non-pharmacological exercise therapy, resveratrol supplementation, and in particular the combination of these two, can be effective in increasing the antioxidant markers and reducing oxidative markers due to hepatitis Diabetes.

Keywords

• diabetes mellitus
• resveratrol
• continuous training
• sod
• gpx and mda.