GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment

Ki-Hoon Song; Mi So Park; Tulip S. Nandu; Shrikanth Gadad; Sang-Cheol Kim; Mi-Young Kim

doi:10.1038/ncomms13796

Nature Communications (Dec 2016)

GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment

Ki-Hoon Song,
Mi So Park,
Tulip S. Nandu,
Shrikanth Gadad,
Sang-Cheol Kim,
Mi-Young Kim

Affiliations

Ki-Hoon Song: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Mi So Park: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Tulip S. Nandu: Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center
Shrikanth Gadad: Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center
Sang-Cheol Kim: Department of Biomedical Informatics, Center for Genome Science, National Institute of Health, KCDC
Mi-Young Kim: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)

DOI: https://doi.org/10.1038/ncomms13796
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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Polypeptide N-acetyl-galactosaminyltransferases (GALNTs) are associated with cancer, but their function in organ-specific metastasis is unclear. Here the authors show that GALNT14 promotes breast cancer metastasis to the lung by enhancing the initiation of metastatic colonies and subsequent growth.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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