Metabolism of the intestinal microbiota in children of the first year of life with intestinal pathology and its surgical correction as a potential marker of biological age

Abstract

The article presents data on the study of the metabolic activity of the intestinal microbiota in children of the first year of life. The study was performed by gas-liquid chromatographic analysis with the determination of short-chain fatty acids (SCFA) in fecal matter, which reflects the microbiota metabolic activity. The content of fecal matter was determined, reflecting the activity of aerobic microbiota-acetic acid (C2); anaerobic microbiota – propionic (C3), butyric (C4) acids; the sum of acids (E); anaerobic index (AI), which is an integral indicator of the intestinal environment. It was found that despite surgical intervention in the intestine in the first months of life, the metabolic activity of microbiota in children with intestinal resection remains stable throughout the first year of life.