Nature Communications (Jul 2022)
Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud
Abstract
The embryonic limb bud is known to be patterned by a Shh morphogen gradient, though how Shh expression is activated remains less clear. Here the authors show that Etv2 acts as a pioneer transcription factor to mediate accessibility of the ZRS enhancer and initiate Shh expression.