Nature Communications (Jan 2023)
A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens
- Kevin B. Weyant,
- Ayomide Oloyede,
- Sukumar Pal,
- Julie Liao,
- Mariela Rivera-De Jesus,
- Thapakorn Jaroentomeechai,
- Tyler D. Moeller,
- Steven Hoang-Phou,
- Sean F. Gilmore,
- Riya Singh,
- Daniel C. Pan,
- David Putnam,
- Christopher Locher,
- Luis M. de la Maza,
- Matthew A. Coleman,
- Matthew P. DeLisa
Affiliations
- Kevin B. Weyant
- Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University
- Ayomide Oloyede
- Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University
- Sukumar Pal
- Department of Pathology and Laboratory Medicine, Medical Sciences, Room D440, University of California, Irvine
- Julie Liao
- Versatope Therapeutics, Inc.
- Mariela Rivera-De Jesus
- Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University
- Thapakorn Jaroentomeechai
- Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University
- Tyler D. Moeller
- Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University
- Steven Hoang-Phou
- Lawrence Livermore National Laboratory
- Sean F. Gilmore
- Lawrence Livermore National Laboratory
- Riya Singh
- Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University
- Daniel C. Pan
- Versatope Therapeutics, Inc.
- David Putnam
- Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University
- Christopher Locher
- Versatope Therapeutics, Inc.
- Luis M. de la Maza
- Department of Pathology and Laboratory Medicine, Medical Sciences, Room D440, University of California, Irvine
- Matthew A. Coleman
- Lawrence Livermore National Laboratory
- Matthew P. DeLisa
- Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University
- DOI
- https://doi.org/10.1038/s41467-023-36101-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
Antigen display on outer membrane vesicles (OMVs) can be difficult to control and highly variable. Here, the authors describe a universal approach called AvidVax for linking biotinylated antigens to the exterior of OMVs and enabling rapid vaccine assembly.
