Size exclusion chromatography as green support for forced degradation study of adalimumab

Abstract

Size exclusion chromatography (SEC) has become a powerful tool for analysing size variants of biologic drugs in their native form. Modern SEC can be defined by the use of chromatographic columns packed with sub-3 µm particles, allowing an increase in method throughput compared to that of conventional SEC.

Keywords

• inflammatory bowel disease
• biopharmaceuticals
• adalimumab
• size exclusion chromatography
• forced degradation study