Nature Communications (Jul 2020)

Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation

  • Ravi Kiran Koripella,
  • Manjuli R. Sharma,
  • Kalpana Bhargava,
  • Partha P. Datta,
  • Prem S. Kaushal,
  • Pooja Keshavan,
  • Linda L. Spremulli,
  • Nilesh K. Banavali,
  • Rajendra K. Agrawal

DOI
https://doi.org/10.1038/s41467-020-17715-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

Read online

Translation within mitochondria is carried out by specialized mitoribosomes and translational factors. Here the authors describe cryo-EM structures of the human mitochondrial translation elongation factor G1 in complex with human mitoribosomes, revealing distinct mechanism that include conformational changes at the polypeptide exit tunnel.