Microsurgical Testicular Sperm Extraction Results in Nonobstructive Azospermic Disease and Evaluation of the Factors Affecting These Results

Abstract

Aim: To investigate the hormonal properties and results of 71 patients, who were diagnosed with nonobstructive azoospermia (NOA) and performed micro-TESE (microsurgical testicular sperm extraction) at our clinic, and the relationship of these results and Johnsen scores. Patients and Method: We retrospectively reviewed the data of 71 patients who came to our clinic and were diagnosed with NOA and got performed micro-TESE between the years of 2010 and 2014. Variables such as age, the duration of infertility, operations underwent, mean testis volumes, blood FSH (follicle stimulated hormone), LH (luteinizing hormone), total testosterone and prolactin levels, results and their relations with sperm retrieval rates were examined. Results: Sperm were found in 25 (35.21%) of 71 patients, who were performed micro-TESE, and 6 (8.45%) of them have developed pregnancy. Mean testis volumes were found 14.3 ± 3.80 (4-22) cc on the right and 13.7 ± 3,41 (4-20) cc on the left. As FSH and LH values increased, the probability of sperm retrieval rate was decreased (p <0.05). There was no correlation between total testosterone and prolactin levels with sperm retrieval in TESE (p> 0,05). Conclusion: In micro-TESE, the success of sperm retrieval can be affected by patient age, having testis operation history, testis volume, patient's hormonal profile. Sperm retrieval success correlates with histology, blood FSH and LH values, if there is a relation sperm retrieval success and patient age, duration of infertility, blood total testosterone, prolactin levels and testis volume is unclear.

Keywords

• infertility
• azospermia
• micro-tese
• i̇nfertilite
• azospermi
• mikrotese