A Review on The Pathogenesis of Cardiovascular Disease of <em>Flaviviridea</em> Viruses Infection
Tie-Hua Yang,
Wen-Cong Gao,
Xin Ma,
Qian Liu,
Pan-Pan Pang,
Yong-Tang Zheng,
Yinnong Jia,
Chang-Bo Zheng
Affiliations
Tie-Hua Yang
School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, China
Wen-Cong Gao
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
Xin Ma
Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China
Qian Liu
School of Pharmacy, Chongqing Medical University, Chongqing 400016, China
Pan-Pan Pang
School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, China
Yong-Tang Zheng
Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China
Yinnong Jia
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
Chang-Bo Zheng
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
Members of the Flaviviridae family, encompassing the Flavivirus and Hepacivirus genera, are implicated in a spectrum of severe human pathologies. These diseases span a diverse spectrum, including hepatitis, vascular shock syndrome, encephalitis, acute flaccid paralysis, and adverse fetal outcomes, such as congenital heart defects and increased mortality rates. Notably, infections by Flaviviridae viruses have been associated with substantial cardiovascular compromise, yet the exploration into the attendant cardiovascular sequelae and underlying mechanisms remains relatively underexplored. This review aims to explore the epidemiology of Flaviviridae virus infections and synthesize their cardiovascular morbidities. Leveraging current research trajectories and our investigative contributions, we aspire to construct a cogent theoretical framework elucidating the pathogenesis of Flaviviridae-induced cardiovascular injury and illuminate prospective therapeutic avenues.
