Nature Communications (Oct 2019)
Early detection and staging of chronic liver diseases with a protein MRI contrast agent
- Mani Salarian,
- Ravi Chakra Turaga,
- Shenghui Xue,
- Maysam Nezafati,
- Khan Hekmatyar,
- Jingjuan Qiao,
- Yinwei Zhang,
- Shanshan Tan,
- Oluwatosin Y. Ibhagui,
- Yan Hai,
- Jibiao Li,
- Rao Mukkavilli,
- Malvika Sharma,
- Pardeep Mittal,
- Xiaoyi Min,
- Shella Keilholz,
- Liqing Yu,
- Gengshen Qin,
- Alton Brad Farris,
- Zhi-Ren Liu,
- Jenny J. Yang
Affiliations
- Mani Salarian
- Department of Chemistry, Georgia State University
- Ravi Chakra Turaga
- Department of Biology, Georgia State University
- Shenghui Xue
- Department of Chemistry, Georgia State University
- Maysam Nezafati
- Department of Biomedical Engineering, Emory University and Georgia Institute of Technology
- Khan Hekmatyar
- Bioimaging Research Center, University of Georgia
- Jingjuan Qiao
- Department of Chemistry, Georgia State University
- Yinwei Zhang
- Department of Biology, Georgia State University
- Shanshan Tan
- Department of Chemistry, Georgia State University
- Oluwatosin Y. Ibhagui
- Department of Chemistry, Georgia State University
- Yan Hai
- Department of Mathematics and Statistics, Georgia State University
- Jibiao Li
- Center for Molecular and Translational Medicine, Georgia State University
- Rao Mukkavilli
- Center for Diagnostics and Therapeutics, Georgia State University
- Malvika Sharma
- Department of Biology, Georgia State University
- Pardeep Mittal
- Medical College of Georgia, Augusta University
- Xiaoyi Min
- Department of Mathematics and Statistics, Georgia State University
- Shella Keilholz
- Department of Biomedical Engineering, Emory University and Georgia Institute of Technology
- Liqing Yu
- Center for Molecular and Translational Medicine, Georgia State University
- Gengshen Qin
- Department of Mathematics and Statistics, Georgia State University
- Alton Brad Farris
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Zhi-Ren Liu
- Department of Biology, Georgia State University
- Jenny J. Yang
- Department of Chemistry, Georgia State University
- DOI
- https://doi.org/10.1038/s41467-019-11984-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Non-invasive early diagnosis of liver fibrosis is important to prevent disease progression and direct treatment strategies. Here the authors developed a collagen-targeting contrast agent for the detection of early stage fibrosis and non-alcoholic steatohepatitis by magnetic resonance and tested it in animal models.
