Microarchitecture of the Augmented Bone Following Sinus Elevation with an Albumin Impregnated Demineralized Freeze-Dried Bone Allograft (BoneAlbumin) versus Anorganic Bovine Bone Mineral: A Randomized Prospective Clinical, Histomorphometric, and Micro-Computed Tomography Study
Kivovics Márton,
Szabó Bence Tamás,
Németh Orsolya,
Czinkóczky Béla,
Dőri Ferenc,
Nagy Péter,
Dobó-Nagy Csaba,
Csönge Lajos,
Lacza Zsombor,
Mijiritsky Eitan,
Szabó György
Affiliations
Kivovics Márton
Department of Community Dentistry, Semmelweis University, Szentkirályi utca 40, 1088 Budapest, Hungary
Szabó Bence Tamás
Department of Oral Diagnostics, Semmelweis University, Szentkirályi utca 47, 1088 Budapest, Hungary
Németh Orsolya
Department of Community Dentistry, Semmelweis University, Szentkirályi utca 40, 1088 Budapest, Hungary
Czinkóczky Béla
Department of Community Dentistry, Semmelweis University, Szentkirályi utca 40, 1088 Budapest, Hungary
Dőri Ferenc
Department of Periodontology, Semmelweis University, Szentkirályi utca 47, 1088 Budapest, Hungary
Nagy Péter
Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, 1085 Budapest, Hungary
Dobó-Nagy Csaba
Department of Oral Diagnostics, Semmelweis University, Szentkirályi utca 47, 1088 Budapest, Hungary
Csönge Lajos
Petz Aladár County Hospital, West Hungarian Regional Tissue Bank, Vasvári Pál u. 2–4, 9024 Győr, Hungary
Lacza Zsombor
Institute of Clinical Experimental Research, Semmelweis University, Tűzoltó u. 37–47, 1094 Budapest, Hungary
Mijiritsky Eitan
Department of Oral Rehabilitation, Tel Aviv University, Ramat Aviv, Tel Aviv 6997801, Israel
Szabó György
Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, Mária utca 52, 1085 Budapest, Hungary
Serum albumin has been identified as an endogenous protein that is integral to early bone regeneration. We hypothesized that albumin addition to allografts may result in better bone remodeling than what can be achieved with anorganic xenografts. Sinus elevations were performed at 32 sites of 18 patients with the lateral window technique. Sites either received filling with an anorganic bovine bone mineral (ABBM, BioOss, Geistlich, CH) or albumin impregnated allograft (BoneAlbumin, OrthoSera, AT). After 6-months patients received dental implants and 16 bone core biopsy samples were obtained from the ABBM filled, and 16 from the BoneAlbumin augmented sites. The biopsies were examined by histomorphometry and µCT. Percentage of the residual graft in the BoneAlbumin group was 0–12.7%, median 5.4% vs. ABBM 6.3–35.9%, median 16.9%, p < 0.05. Results of the µCT analysis showed that the microarchitecture of the augmented bone in the BoneAlbumin group resembles that of the native maxilla in morphometric parameters Trabecular Pattern Factor and Connectivity. Our data show that while ABBM successfully integrates into the newly formed bone tissue as persisting particles, BoneAlbumin is underway towards complete remodeling with new bone closely resembling that of the intact maxilla.
