Frontiers in Allergy (Jan 2024)
Pre-asthma: a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1—allergic asthma
- G. K. Scadding,
- G. K. Scadding,
- M. McDonald,
- V. Backer,
- G. Scadding,
- M. Bernal-Sprekelsen,
- M. Bernal-Sprekelsen,
- D. M. Conti,
- E. De Corso,
- Z. Diamant,
- Z. Diamant,
- Z. Diamant,
- Z. Diamant,
- C. Gray,
- C. Gray,
- C. Hopkins,
- M. Jesenak,
- M. Jesenak,
- M. Jesenak,
- P. Johansen,
- P. Johansen,
- J. Kappen,
- J. Mullol,
- D. Price,
- D. Price,
- S. Quirce,
- S. Reitsma,
- S. Salmi,
- S. Salmi,
- B. Senior,
- J. P. Thyssen,
- U. Wahn,
- P. W. Hellings,
- P. W. Hellings,
- P. W. Hellings
Affiliations
- G. K. Scadding
- Department of Allergy & Rhinology, Royal National ENT Hospital, London, United Kingdom
- G. K. Scadding
- Division of Immunity and Infection, University College, London, United Kingdom
- M. McDonald
- The Allergy Clinic, Blairgowrie, Randburg, South Africa
- V. Backer
- Department of Otorhinolaryngology, Head & Neck Surgery, and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark
- G. Scadding
- Allergy, Royal Brompton Hospital, London, United Kingdom
- M. Bernal-Sprekelsen
- Head of ORL-Deptartment, Clinic Barcelona, Barcelona, Spain
- M. Bernal-Sprekelsen
- Chair of ORL, University of Barcelona, Barcelona, Spain
- D. M. Conti
- The European Forum for Research and Education in Allergy and Airway Diseases Scientific Expert Team Members, Brussels, Belgium
- E. De Corso
- Otolaryngology Head and Neck Surgery, A. Gemelli University Hospital Foundation IRCCS, Rome, Italy
- Z. Diamant
- 0Department of Respiratory Medicine & Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden
- Z. Diamant
- 1Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic
- Z. Diamant
- 2Department Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
- Z. Diamant
- 3Deptarment of Microbiology Immunology & Transplantation, KU Leuven, Catholic University of Leuven, Leuven, Belgium
- C. Gray
- 4Paediatric Allergist, Red Cross Children’s Hospital and University of Cape Town, Cape Town, South Africa
- C. Gray
- 5Kidsallergy Centre, Cape Town, South Africa
- C. Hopkins
- 6Department of Rhinology and Skull Base Surgery, Guy’s and St Thomas’ Hospital NHS Foundation Trust, London, United Kingdom
- M. Jesenak
- 7Department of Clinical Immunology and Allergology, University Teaching Hospital in Martin, Martin, Slovakia
- M. Jesenak
- 8Department of Paediatrics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Teaching Hospital in Martin, Martin, Slovakia
- M. Jesenak
- 9Department of Pulmonology and Phthisiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Teaching Hospital in Martin, Martin, Slovakia
- P. Johansen
- 0Department of Dermatology, University of Zurich, Zurich, Switzerland
- P. Johansen
- 1Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
- J. Kappen
- 2Department of Pulmonology, STZ Centre of Excellence for Asthma, COPD and Respiratory Allergy, Franciscus Gasthuis & Vlietland, Rotterdam, Netherlands
- J. Mullol
- 3Rhinology Unit and Smell Clinic, ENT Department, Hospital Clínic, FRCB-IDIBAPS, Universitat de Barcelona, CIBERES, Barcelona, Spain
- D. Price
- 4Observational and Pragmatic Research Institute, Singapore, Singapore
- D. Price
- 5Division of Applied Health Sciences, Centre of Academic Primary Care, University of Aberdeen, Aberdeen, United Kingdom
- S. Quirce
- 6Department of Allergy, La Paz University Hospital, IdiPAZ, Madrid, Spain
- S. Reitsma
- 7Department of Otorhinolarynogology and Head/Neck Surgery, Amsterdam University Medical Centres, Location AMC, University of Amsterdam, Amsterdam, Netherlands
- S. Salmi
- 8Department of Otorhinolaryngology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
- S. Salmi
- 9Department of Allergy, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
- B. Senior
- 0Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
- J. P. Thyssen
- 1Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
- U. Wahn
- 2Former Head of the Department for Pediatric Pneumology and Immunology, Charite University Medicine, Berlin, Germany
- P. W. Hellings
- 3Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals, Leuven, Belgium
- P. W. Hellings
- 4Laboratory of Allergy and Clinical Immunology, University Hospitals Leuven, Leuven, Belgium
- P. W. Hellings
- 5Upper Airways Research Laboratory, Department of Head and Skin, Ghent University, Ghent, Belgium
- DOI
- https://doi.org/10.3389/falgy.2023.1291185
- Journal volume & issue
-
Vol. 4
Abstract
Asthma, which affects some 300 million people worldwide and caused 455,000 deaths in 2019, is a significant burden to suffers and to society. It is the most common chronic disease in children and represents one of the major causes for years lived with disability. Significant efforts are made by organizations such as WHO in improving the diagnosis, treatment and monitoring of asthma. However asthma prevention has been less studied. Currently there is a concept of pre- diabetes which allows a reduction in full blown diabetes if diet and exercise are undertaken. Similar predictive states are found in Alzheimer's and Parkinson's diseases. In this paper we explore the possibilities for asthma prevention, both at population level and also investigate the possibility of defining a state of pre-asthma, in which intensive treatment could reduce progression to asthma. Since asthma is a heterogeneous condition, this paper is concerned with allergic asthma. A subsequent one will deal with late onset eosinophilic asthma.
Keywords
