Nature Communications (May 2022)
Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics
- Kaori Kanemaru,
- Makoto Shimozawa,
- Manabu Kitamata,
- Rikuto Furuishi,
- Hinako Kayano,
- Yui Sukawa,
- Yuuki Chiba,
- Takatsugu Fukuyama,
- Junya Hasegawa,
- Hiroki Nakanishi,
- Takuma Kishimoto,
- Kazuya Tsujita,
- Kazuma Tanaka,
- Toshiki Itoh,
- Junko Sasaki,
- Takehiko Sasaki,
- Kiyoko Fukami,
- Yoshikazu Nakamura
Affiliations
- Kaori Kanemaru
- Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science
- Makoto Shimozawa
- Laboratory of Genome and Biosignals, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
- Manabu Kitamata
- Laboratory of Genome and Biosignals, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
- Rikuto Furuishi
- Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science
- Hinako Kayano
- Laboratory of Genome and Biosignals, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
- Yui Sukawa
- Laboratory of Genome and Biosignals, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
- Yuuki Chiba
- Laboratory of Genome and Biosignals, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
- Takatsugu Fukuyama
- Laboratory of Genome and Biosignals, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
- Junya Hasegawa
- Department of Biochemical Pathophysiology, Medical Research Institute, Tokyo Medical and Dental University
- Hiroki Nakanishi
- Research Center for Biosignal, Akita University
- Takuma Kishimoto
- Division of Molecular Interaction, Institute for Genetic Medicine, Hokkaido University Graduate School of Life Science
- Kazuya Tsujita
- Biosignal Research Center, Kobe University
- Kazuma Tanaka
- Division of Molecular Interaction, Institute for Genetic Medicine, Hokkaido University Graduate School of Life Science
- Toshiki Itoh
- Biosignal Research Center, Kobe University
- Junko Sasaki
- Department of Biochemical Pathophysiology, Medical Research Institute, Tokyo Medical and Dental University
- Takehiko Sasaki
- Department of Biochemical Pathophysiology, Medical Research Institute, Tokyo Medical and Dental University
- Kiyoko Fukami
- Laboratory of Genome and Biosignals, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
- Yoshikazu Nakamura
- Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science
- DOI
- https://doi.org/10.1038/s41467-022-30061-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Epithelial cells provide cell-cell adhesion to maintain the integrity of multicellular organisms. Here the authors show that phospholipid phosphatidylinositol (4,5)-bisphosphate is critical for the maintenance of epithelial characteristics.
