Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity mapping

Abstract

Highlights 1. We established an optogenetic mouse CSD model without irritation dura, which could mimic the behaviors of headache and photophobia. 2. It was the first time to depict a broad, unbiased neuronal activity map throughout the mouse brain after CSD. 3. Results of whole brain image and immunofluorescence staining showed that optogenetic CSD could activate multiple sensory-related networks without activating thalamus or TNC to induce cortical pain.

Keywords

• Cortical spreading depression
• Whole-brain activity mapping
• Cortical pain