Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations
Milan Toma,
Daniel R. Einstein,
Keshav Kohli,
Sheridan L. Caroll,
Charles H. Bloodworth,
Richard P. Cochran,
Karyn S. Kunzelman,
Ajit P. Yoganathan
Affiliations
Milan Toma
Department of Osteopathic Manipulative Medicine, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury Campus, Northern Boulevard, Old Westbury, NY 11568-8000, USA
Daniel R. Einstein
Department of Mechanical Engineering, St. Martin’s University, 5000 Abbey Way SE, Lacey, WA 98503, USA
Keshav Kohli
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, 387 Technology Circle, Atlanta, GA 30313-2412, USA
Sheridan L. Caroll
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, 387 Technology Circle, Atlanta, GA 30313-2412, USA
Charles H. Bloodworth
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, 387 Technology Circle, Atlanta, GA 30313-2412, USA
Richard P. Cochran
Department of Mechanical Engineering, University of Maine, 219 Boardman Hall, Orono, ME 04469-5711, USA
Karyn S. Kunzelman
Department of Mechanical Engineering, University of Maine, 219 Boardman Hall, Orono, ME 04469-5711, USA
Ajit P. Yoganathan
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, 387 Technology Circle, Atlanta, GA 30313-2412, USA
Edge-to-edge repair for mitral valve regurgitation is being increasingly performed in high-surgical risk patients using minimally invasive mitral clipping devices. Known procedural complications include chordal rupture and mitral leaflet perforation. Hence, it is important to quantitatively evaluate the effect of edge-to-edge repair on chordal integrity. in this study, we employ a computational mitral valve model to simulate functional mitral regurgitation (FMR) by creating papillary muscle displacement. Edge-to-edge repair is then modeled by simulated coaptation of the mid portion of the mitral leaflets. in the setting of simulated FMR, edge-to-edge repair was shown to sustain low regurgitant orifice area, until a two fold increase in the inter-papillary muscle distance as compared to the normal mitral valve. Strain in the chordae was evaluated near the papillary muscles and the leaflets. Following edge-to-edge repair, strain near the papillary muscles did not significantly change relative to the unrepaired valve, while strain near the leaflets increased significantly relative to the unrepaired valve. These data demonstrate the potential for computational simulations to aid in the pre-procedural evaluation of possible complications such as chordal rupture and leaflet perforation following percutaneous edge-to-edge repair.
