Nature Communications (Sep 2021)
DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
- Rajbir Nath Batra,
- Aviezer Lifshitz,
- Ana Tufegdzic Vidakovic,
- Suet-Feung Chin,
- Ankita Sati-Batra,
- Stephen-John Sammut,
- Elena Provenzano,
- H. Raza Ali,
- Ali Dariush,
- Alejandra Bruna,
- Leigh Murphy,
- Arnie Purushotham,
- Ian Ellis,
- Andrew Green,
- Francine E. Garrett-Bakelman,
- Chris Mason,
- Ari Melnick,
- Samuel A. J. R. Aparicio,
- Oscar M. Rueda,
- Amos Tanay,
- Carlos Caldas
Affiliations
- Rajbir Nath Batra
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge
- Aviezer Lifshitz
- Department of Computer Science and Applied Mathematics, and Department of Biological Regulation, Weizmann Institute of Science
- Ana Tufegdzic Vidakovic
- Mechanisms of Transcription Laboratory, The Francis Crick Institute
- Suet-Feung Chin
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge
- Ankita Sati-Batra
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge
- Stephen-John Sammut
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge
- Elena Provenzano
- Cancer Research UK Cambridge Centre
- H. Raza Ali
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge
- Ali Dariush
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge
- Alejandra Bruna
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge
- Leigh Murphy
- Research Institute in Oncology and Hematology
- Arnie Purushotham
- School of Cancer and Pharmaceutical Sciences, King’s College London
- Ian Ellis
- Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospital NHS Trust
- Andrew Green
- Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospital NHS Trust
- Francine E. Garrett-Bakelman
- Division of Hematology and Medical Oncology, Weill Cornell Medicine
- Chris Mason
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Ari Melnick
- Division of Hematology and Medical Oncology, Weill Cornell Medicine
- Samuel A. J. R. Aparicio
- Department of Molecular Oncology, British Columbia Cancer Research Centre
- Oscar M. Rueda
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge
- Amos Tanay
- Department of Computer Science and Applied Mathematics, and Department of Biological Regulation, Weizmann Institute of Science
- Carlos Caldas
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-021-25661-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Understanding the molecular mechanisms underlying DNA methylation in cancer and its clinical relevance remains crucial. Here, the authors study RRBS-based profiles of 1538 breast tumours and 244 normal breast tissues from the METABRIC cohort and report epigenomic instability and cis-regulatory effects.
