Nature Communications (Feb 2021)
Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
- Yong-Fei Wang,
- Yan Zhang,
- Zhiming Lin,
- Huoru Zhang,
- Ting-You Wang,
- Yujie Cao,
- David L. Morris,
- Yujun Sheng,
- Xianyong Yin,
- Shi-Long Zhong,
- Xiaoqiong Gu,
- Yao Lei,
- Jing He,
- Qi Wu,
- Jiangshan Jane Shen,
- Jing Yang,
- Tai-Hing Lam,
- Jia-Huang Lin,
- Zhi-Ming Mai,
- Mengbiao Guo,
- Yuanjia Tang,
- Yanhui Chen,
- Qin Song,
- Bo Ban,
- Chi Chiu Mok,
- Yong Cui,
- Liangjing Lu,
- Nan Shen,
- Pak C. Sham,
- Chak Sing Lau,
- David K. Smith,
- Timothy J. Vyse,
- Xuejun Zhang,
- Yu Lung Lau,
- Wanling Yang
Affiliations
- Yong-Fei Wang
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- Yan Zhang
- Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Zhiming Lin
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University
- Huoru Zhang
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- Ting-You Wang
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- Yujie Cao
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- David L. Morris
- Division of Genetics and Molecular Medicine, King’s College London
- Yujun Sheng
- Department of Dermatology, No.1 Hospital, Anhui Medical University
- Xianyong Yin
- Department of Dermatology, No.1 Hospital, Anhui Medical University
- Shi-Long Zhong
- Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital
- Xiaoqiong Gu
- Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center
- Yao Lei
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- Jing He
- Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Qi Wu
- Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Jiangshan Jane Shen
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- Jing Yang
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- Tai-Hing Lam
- School of Public Health, The University of Hong Kong
- Jia-Huang Lin
- School of Public Health, The University of Hong Kong
- Zhi-Ming Mai
- School of Public Health, The University of Hong Kong
- Mengbiao Guo
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- Yuanjia Tang
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Yanhui Chen
- Department of Pediatrics, Union Hospital Affiliated to Fujian Medical University
- Qin Song
- Department of Rheumatology, Affiliated Hospital of Jining Medical University
- Bo Ban
- Department of Endocrinology, Affiliated Hospital of Jining Medical University
- Chi Chiu Mok
- Department of Medicine, Tuen Mun Hospital
- Yong Cui
- Department of Dermatology, China-Japan Friendship Hospital
- Liangjing Lu
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Nan Shen
- Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Pak C. Sham
- Department of Psychiatry, The University of Hong Kong
- Chak Sing Lau
- Department of Medicine, The University of Hong Kong
- David K. Smith
- School of Public Health, The University of Hong Kong
- Timothy J. Vyse
- Division of Genetics and Molecular Medicine, King’s College London
- Xuejun Zhang
- Department of Dermatology, No.1 Hospital, Anhui Medical University
- Yu Lung Lau
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- Wanling Yang
- Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-021-21049-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
The presentation of systemic lupus erythematosus has been known to differ by ancestry, but the underlying genetic factors remain unclear. Here, the authors report ancestry-specific susceptibility loci and better risk prediction when using data from matched ancestral groups.
