INFRINGEMENT OF ANGIOGENESIS AND SCLEROSIS REGULATION PROCESSES IN HYPERPLASTIC ENDOMETRIUM

Abstract

Pathomorphological and immunohistochemical studies of endometrium were performed. The higher proliferative activity of the VEGF and the higher production of transformation growth factor β1 (TGFβ1), fibronectin and liziloxydaza in patiens with atypical hyperplasia of endometrium and chronic endometritis testifies the presence of cellular hypoxia, disturbance of intercellular and extracellular interaction and can be considered as the negative prognostic factor.

Keywords

• hyperplastic processes of endometrium
• chronic endometritis
• liziloxydaza
• vascular endothelial growth factor
• transformation growth factor β1
• fibronectin