Effect of T-2 Toxin in Combination with Vitamin E, Selenium and Mycotoxin Binder on Lipid Peroxide Status and on the Glutathione Redox System in Broiler Chicken

Abstract

The effect of T-2 toxin (2.35mg/kg of feed) on lipid peroxidation and on the antioxidant defence system was studied in blood plasma, red blood cells (RBC), liver and spleen of broiler chickens. The influences of antioxidant vitamin E (10.5mg/animal/day)+selenium (0.045mg/animal/day) and toxin binder (yeast cell wall extract, 2mg/kg of feed) supplementations on pathophysiological changes associated with the consumption of T-2 toxin contaminated feed was also investigated. T-2 toxin did not enhance the lipid peroxidation processes but had effect on the ascorbic acid and glutathione redox system. The antioxidant and toxin binder supplementation beside T-2 toxin load has beneficial effect on the antioxidant status, primarily the activity of the glutathione peroxidase (GSH-Px).

Keywords

• glutathione
• glutathione-peroxidase
• lipid peroxidation
• t-2 toxin
• vitamin c