BMJ Open (Oct 2024)

Assessment of bleeding events in patients receiving DOACs with or without statins to treat venous thromboembolism: insights from the RIETE registry

  • Dominique Farge-bancel,
  • R Marqués,
  • M Ortiz,
  • Paolo Prandoni,
  • J Roa,
  • Manuel Monreal,
  • F Couturaud,
  • J Gutierrez,
  • J Pagan,
  • Peter Verhamme,
  • A Aujayeb,
  • Laurent Bertoletti,
  • P Verhamme,
  • M Monreal,
  • S Fonseca,
  • S Pinto,
  • S Soler,
  • A Lorenzo,
  • R Lecumberri,
  • R Otero,
  • P DI MICCO,
  • F Rivera-Cívico,
  • A Molino,
  • P Suchon,
  • C Grange,
  • JA Caprini,
  • J Osorio,
  • Henri Bounameaux,
  • R Valle,
  • F Negro,
  • A Tufano,
  • Remedios Otero,
  • Aitor Ballaz,
  • G Kenet,
  • I Francisco,
  • F Uresandi,
  • G Barillari,
  • Marijan Bosevski,
  • F García-Bragado,
  • E Grau,
  • D Jiménez,
  • A Maestre,
  • A Visonà,
  • J Criado,
  • R Chopard,
  • I Weinberg,
  • M Lumbierres,
  • B Leclercq,
  • H Bounameaux,
  • Farid Rashidi,
  • Abílio Reis,
  • Lucia Mazzolai,
  • P Llamas,
  • MJ Núñez-Fernández,
  • F Dentali,
  • O Espitia,
  • C Siniscalchi,
  • Rosaria Del Giorno,
  • Sanjiv Keller,
  • Carmine Siniscalchi,
  • Luciano Lopez-Jimenez,
  • Ana Cristina Montenegro,
  • Benjamin Brenner,
  • Raquel Barb,
  • Pierpaolo Di Micco,
  • Sebastian Schellong,
  • Inna Tzoran,
  • Radovan Malý,
  • Joseph A. Caprini,
  • Hanh My Bui,
  • MD Adarraga,
  • A Alberich-Conesa,
  • J Aibar,
  • A Alda-Lozano,
  • J Alfonso,
  • C Amado,
  • M Angelina-García,
  • JI Arcelus,
  • A Ballaz,
  • R Barba,
  • C Barbagelata,
  • M Barrón,
  • B Barrón-Andrés,
  • F Beddar-Chaib,
  • A Blanco-Molina,
  • JC Caballero,
  • J Carrillo-Alonso,
  • G Castellanos,
  • L Chasco,
  • C De Ancos,
  • J Del Toro,
  • P Demelo-Rodríguez,
  • C De Juana-Izquierdo,
  • MC Díaz-Pedroche,
  • JA Díaz-Peromingo,
  • A Dubois-Silva,
  • JC Escribano,
  • C Falgá,
  • AI Farfán-Sedano,
  • C Fernández-Aracil,
  • C Fernández-Capitán,
  • B Fernández-Jiménez,
  • JL Fernández-Reyes,
  • MA Fidalgo,
  • C Gabara,
  • F Galeano-Valle,
  • C García-González,
  • A García-Ortega,
  • O Gavín-Sebastián,
  • MA Gil-De Gómez,
  • A Gil-Díaz,
  • C Gómez-Cuervo,
  • A González-Munera,
  • L Guirado,
  • L Hernández-Blasco,
  • L Jara-Palomares,
  • MJ Jaras,
  • I Jou,
  • MD Joya,
  • JL Lobo,
  • L López-Jiménez,
  • P López-Miguel,
  • H López-Brull,
  • JJ López-Núñez,
  • A López-Ruiz,
  • JB LópezSáez,
  • O Madridano,
  • PJ Marchena,
  • M Marcos,
  • M Martín del Pozo,
  • F Martín-Martos,
  • R Martínez-Prado,
  • JM Maza,
  • E Mena,
  • MI Mercado,
  • J Moisés,
  • MV Morales,
  • MS Navas,
  • JA Nieto,
  • M Olid,
  • L Ordieres-Ortega,
  • S Otálora,
  • N Pacheco-Gómez,
  • AC Palomeque,
  • E Paredes,
  • P Parra-Caballero,
  • P Parra-Rosado,
  • JM Pedrajas,
  • C Pérez-Ductor,
  • M Pérez-Pinar,
  • MA Pérez-Jacoiste,
  • ML Peris,
  • ML Pesce,
  • JA Porras,
  • R Puchades,
  • A Rodríguez-Cobo,
  • M Romero-Brugera,
  • P Ruiz-Artacho,
  • N Ruiz-Giménez,
  • J Ruiz-Ruiz,
  • G Salgueiro,
  • T Sancho,
  • V Sendín,
  • P Sigüenza,
  • A Steinherr,
  • S Suárez-Fernández,
  • R Tirado,
  • A TorrentsVilar,
  • MI Torres,
  • J Trujillo-Santos,
  • JF Varona,
  • A Villalobos,
  • P Villares,
  • C Ay,
  • S Nopp,
  • I Pabinger,
  • C Van Edom,
  • A Verstraete,
  • Yoo HHB,
  • AC Montenegro,
  • SN Morales,
  • J Hirmerova,
  • R Malý,
  • L Bertoletti,
  • A BuraRiviere,
  • J Catella,
  • R Le Mao,
  • I Mahé,
  • F Moustafa,
  • L Plaisance,
  • G Sarlon-Bartoli,
  • E Versini,
  • S Schellong,
  • B Brenner,
  • I Tzoran,
  • P Sadeghipour,
  • F Rashidi,
  • A Abenante,
  • M Basaglia,
  • M Bertoni,
  • F Bilora,
  • B Brandolin,
  • M Ciammaichella,
  • D Colaizzo,
  • E Grandone,
  • E Imbalzano,
  • R Pesavento,
  • A Poz,
  • P Prandoni,
  • B Taflaj,
  • B Zalunardo,
  • A Skride,
  • D Kigitovica,
  • J Meireles,
  • M Bosevski,
  • M Zdraveska,
  • L Mazzolai,
  • HM Bui

DOI
https://doi.org/10.1136/bmjopen-2024-085401
Journal volume & issue
Vol. 14, no. 10

Abstract

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Objective To evaluate the impact of coadministering statins with direct oral anticoagulants (DOACs) on the risk of major bleeding events in patients with venous thromboembolism (VTE).Design Observational cohort analysis based on a multicentre international registry.Setting Data were extracted from the Registro Informatizado de Enfermedad TromboEmbolica Registry, which involves 205 centres across 27 countries.Participants A total of 73 659 patients diagnosed with VTE were classified based on their anticoagulant therapy (DOACs) versus low-molecular-weight heparin (LMWH) or vitamin K antagonists (VKAs) and concurrent use of statins.Methods Multivariable Cox proportional hazards models adjusted for confounding variables to assess the risk of major bleeding events stratified by the type of anticoagulant use and statin use.Results From October 2013 to February 2023, 73 659 patients were recruited: 2573 were statin users on DOACs, 14 090 were statin users on LMWH or VKA therapy, 10 088 were non-statin users on DOACs and 46 908 were non-statin users on LMWH or VKA therapy. Statin users were 10 years older and more likely to have hypertension, diabetes, renal failure or prior artery disease. During anticoagulation (median, 187 days), 1917 patients (2.6%) suffered major bleeding. Rates of major bleeding per 100 patient-years were 2.33 (95% CI 1.72 to 3.09), 3.75 (95% CI 3.43 to 4.10), 1.39 (95% CI 1.13 to 1.69) and 3.10 (95% CI 2.93 to 3.27), respectively. On multivariable analysis, patients treated with DOACs had a significantly lower risk of major bleeding compared with those on LMWH or VKA therapy (adjusted HR 0.59; 95% CI 0.48 to 0.74). The adjusted HR in statin users versus non-users was 1.03 (95% CI 0.92 to 1.14), while in statin users on DOACs versus the rest of patients, it was 1.18 (95% CI 0.79 to 1.76).Conclusions In patients with VTE receiving statins, long-term anticoagulation with DOACs was associated with a reduced risk of major bleeding, regardless of the statin use. These findings support the safety profile of DOACs over VKAs or LMWH in the management of VTE in patients requiring statins.